Active material: Tsefazolyn
When ATH: J01DB04
CCF: I generation Cephalosporin
When CSF: 06.02.01
Manufacturer: LDP – Laboratorios TORLAN (Spain)
| Powder for solution for injection | 1 fl. |
| tsefazolyn (sodium salt) | 1 g |
Bottles (1) – коробки картонные.
I generation cephalosporin antibiotic broad spectrum. It has bactericidal activity.
Active against gram-positive bacteria: Staphylococcus spp. (strains, producing and not producing penicillinase), Streptococcus spp. (incl. Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram negative bacteria: Neisseria meningitidis, Neisseria gonorrhoeae, Shigella spp., Salmonella spp., Escherichia coli, Klebsiella spp.
It is also active against Spirochaetoceae, Leptospira spp.
Inactive against Pseudomonas aeruginosa, indole-positive strains of Proteus spp., Mycobacterium tuberculosis, Anaerobic bacteria.
Cefazolin is poorly absorbed from the gastrointestinal tract and is therefore used in the / m or /. After the / m dose 500 mg Cmax
plasma achieved through 1-2 h is 30 ug / ml.Plasma protein binding is about 85%.
Cefazolin penetrates into the bone tissue, ascitic fluid, pleural fluid and synovial, but not detected in the CNS.
T1/2 cefazolin plasma is about 1.8 no.
Cefazolin is excreted in the urine in unchanged form, mainly, путем клубочковой фильтрации и в небольшой степени – путем канальцевой секреции. After the / m, at least, 80% dose after the / m output through 24 no. After the / m of doses 500 mg 1 г Cmax urine is respectively 1 mg / ml 4 mg / ml.
There is evidence that high concentrations of cefazolin in bile, Although it appears that by a small amount.
T1/2 plasma is increased in patients with impaired renal function.
Infectious-inflammatory diseases, caused by organisms susceptible to cefazolin, incl. diseases of the upper and lower respiratory tract, urinary and biliary tract, pelvic, skin and soft tissue, bone and joints, endokardit, sepsis, peritonitis, otitis media, osteomyelitis, mastitis, Wound, burns and postoperative infections, syphilis, gonorrhea.
Establish individually, taking into account the severity and localization of infection, susceptibility.
Enter the / m or / (bolus or infusion). The average daily dose for adults is 1 g, частота введения – 2-4 times / day.
For the prevention of post-operative infection is administered in a dose of 1 d for 30 minutes before the operation, 0.5-1 g during operation and 0.5-1 g every 6-8 hours within a day after surgery.
The maximum dose: 6 g / day.
For children, the average daily dose is 20-40 mg / kg; in severe infections the dose can be increased to 100 mg / kg / day. The duration of treatment is 7-10 days.
From the digestive system: nausea, vomiting, diarrhea; редко – транзиторное повышение активности печеночных трансаминаз.
Allergic reactions: possible urticaria, itching, eozinofilija, fever; в единичных случаях – отек Квинке, artralgii, anaphylactic shock.
Effects, caused by chemotherapeutic action: candidiasis, psevdomembranoznыy colitis.
From the hematopoietic system: редко – обратимая лейкопения, neutropenia, thrombocytopenia.
From the urinary system: редко – нарушение функции почек.
Local reactions: possible pain at the / m injection.
Children up to age 1 of the month, Hypersensitivity to cephalosporins.
It penetrates through the placental barrier.
In breast milk it is determined by low concentrations of cefazolin.
Use in pregnancy and lactation is justified only in cases, the expected benefit to the mother outweighs the potential risk to the fetus or child.
To use caution in renal impairment.
In patients with hypersensitivity to penicillin allergic reaction to cephalosporin antibiotics.
During treatment possible false positive reaction of urine for sugar.
Cefazolin appear in hemodialysis.
При одновременном применении с “петлевыми” диуретиками происходит блокада канальцевой секреции цефазолина (this combination is not recommended).
Cefazolin may cause disulfiramopodobnye reactions while the use of ethanol.
Probenecid excretion violates cefazolin.
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