Active material: Zopiclone
When ATH: N05CF01
CCF: Sleeping pills
When CSF: 02.07.01.04
Manufacturer: AVENTIS Laboratories (France)
| Pills, covered shell | 1 tab. |
| zopiclone | 7.5 mg |
10 PC. – упаковки ячейковые контурные (2) – пачки картонные.
20 PC. – упаковки ячейковые контурные (1) – пачки картонные.
Hypnotic from the group of tsiklopirrolona. “Небензодиазепиновый” агонист бензодиазепиновых рецепторов. It has also a sedative, anxiolytic, central muscle-relaxing, anticonvulsant and amnesic properties. Like benzodiazepines zopiclone increases GABA-ergic processes in the brain, vzaymodeystvuya with benzodyazepynovыmy receptors, The resulting increased sensitivity to GABA neurotransmitter-receptor. But, zopiclone, apparently, It interacts with other portions of the benzodiazepine receptor, than benzodiazepines.
Zopiclone reduces sleep time, reduces the number of night awakenings, increases total sleep time. Virtually no effect on sleep structure, It does not reduce significantly the amount of REM sleep. The phenomena of the effects on waking expressed little or no. Readmission of zopiclone are not accompanied by cumulation.
Quickly and completely absorbed from the gastrointestinal tract. Cmax achieved through 1-3 no. Easily passes through the blood-tissue barriers, including GEB, and spread to organs and tissues, incl. brain. T1/2 – 5.5-6 no; not koumouliruet.
Sleep disorders (difficulty zasыpaniya, frequent nocturnal awakenings, early awakening), transitory, situational and chronic insomnia; sleep disorders in psychiatric disorders, bronchial asthma with night attacks (in combination with a single administration of the daily dose of theophylline).
Average therapeutic dose is 7.5 mg orally at night, in cases of severe insomnia dose can be increased to 15 mg. In elderly patients, as well as abnormal liver function apply 3.75 mg.
From the digestive system: feeling the bitter or metallic taste in the mouth, dry mouth, nausea, vomiting.
CNS: dizziness, headache, drowsiness, confusion, anterogradnaya amnesia, hallucinations, nightmares.
Dermatological reactions: skin rash.
Severe respiratory failure, pregnancy, lactation (breast-feeding), childhood and adolescence up 15 years, Hypersensitivity to zopiclone.
Zopiclone is contraindicated during pregnancy and lactation (breast-feeding).
Be wary appointed to severe hepatic insufficiency.
The risk of drug dependence minimum, if the duration of the use of zopiclone does not exceed 4 weeks. But, potential risk of dependence to Zopiclone there.
The treatment should be deleted alcohol.
Effects on ability to drive vehicles and management mechanisms
The next day, after taking the drug with caution to drive and use machines.
When applied simultaneously reduces trimipramine concentration in plasma and its effect.
Zopiclone increases the influence of drugs, CNS depressants (incl. ethanol).
This site uses cookies and services to collect technical data from visitors to ensure performance and improve the quality of service.. By continuing to use our site, you automatically agree to the use of these technologies.
Read More