Furamag: instructions for using the medicine, structure, Contraindications
Active material: Furazidin
When ATH: J01XE
CCF: Antibacterial preparative, nitrofuran derivative
ICD-10 codes (testimony): L01, L02, L03, L08.0, N10, N30, N34, N70, N71, N72, T79.3, Z29.2
When CSF: 06.20.01
Manufacturer: OLINEFARM AS (Latvia)
Furamag: dosage form, composition and packaging
Capsules hard gelatin, size №4, brown-yellow; contents of capsules – powder from orange-brown to reddish-brown, allowed to have white particles, yellow, orange and orange-brown color.
| 1 caps. | |
| furazidin (in the form of potassium salt) | 25 mg |
Excipients: magnesium hydroxycarbonate, potassium carbonate, talc.
The composition of the gelatin capsule №4: Titanium dioxide (E171), dye iron oxide yellow (E172), gelatin.
10 PC. – blisters (2) – packs cardboard.
10 PC. – blisters (3) – packs cardboard.
10 PC. – blisters (4) – packs cardboard.
10 PC. – blisters (5) – packs cardboard.
Capsules hard gelatin, size №3, yellow color; contents of capsules – powder from orange-brown to reddish-brown, allowed to have white particles, yellow, orange and orange-brown color.
| 1 caps. | |
| furazidin (in the form of potassium salt) | 50 mg |
Excipients: magnesium carbonate basic, potassium carbonate, talc.
The composition of the gelatin capsule №3: Titanium dioxide (E171), quinoline yellow dye (E104), gelatin.
10 PC. – blisters (2) – packs cardboard.
10 PC. – blisters (3) – packs cardboard.
10 PC. – blisters (4) – packs cardboard.
10 PC. – blisters (5) – packs cardboard.
Furamag: pharmachologic effect
Broad spectrum antimicrobial agent, belonging to the group of nitrofurans.
Resistance to Furamagu® It progresses slowly and does not reach a high degree of.
Active against Gram-positive cocci: Streptococcus spp., Staphylococcus spp.; Gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Proteus is wonderful, Klebsiella spp., Enterobacter spp.; protozoa: Lamblia intestinalis and other microorganisms, antibiotic resistant.
With respect to Staphylococcus spp., Escherichia coli, Aerobacter aerogenes, Leuconostoc citrovorum, Proteus is wonderful, Proteus morganii Furamag®, compared with other nitrofurans, more active.
Against most of the bacteria bacteriostatic concentration is 1:100 000 to 1:200 000. The bactericidal concentration is about 2 times.
Under the influence of nitrofurans in microorganisms, the respiratory chain and the tricarboxylic acid cycle are suppressed. (Krebs cycle), and the oppression of other biochemical processes of microorganisms, resulting in the destruction of their membrane or cytoplasmic membrane.
As a result of nitrofurans microorganisms produce less toxins, therefore the improvement of the general condition of the patient may still expressed to inhibit the growth of microflora. Nitrofurans activate the immune system: titer of complement and enhance the ability of leukocytes phagocytose microorganisms. Furazidin therapeutic doses stimulates leucopoiesis.
Furamag: pharmacokinetics
Absorption
After oral administration furazidin absorbed in the small intestine by passive diffusion. Suction nitrofurans from the distal segment of the small intestine than absorption from the proximal and medial segments respectively 2 and 4 times (It should be taken into account while treating urogenital infections and gastrointestinal diseases, in particular chronic enteritis). Nitrofurans are poorly absorbed from the colon.
Cmax in the blood plasma is retained by 3 to 7 or 8 no, furazidin detected in urine by 3-4 no.
It is a mixture of potassium salt and magnesium carbonate furazidina principal in the ratio 1:1, Furamag® in oral administration has a higher bioavailability, than a simple furazidin (after receiving the capsule Furamaga® in the acidic environment of the stomach does not occur in the conversion furazidina poorly soluble potassium furazidin).
Distribution
In the body is distributed evenly furazidin. Clinically important drug in high content lymph (delay the spread of infection through the lymphatic pathways). The bile concentration in several times higher, than serum, and in the cerebrospinal fluid – several times lower, than serum. The saliva content is furazidina 30% its concentration in serum. Furazidina concentration in the blood and tissues of a relatively small, due to its rapid release, wherein the concentration is significantly higher in the urine, than in blood.
Metabolism
Slightly biotransformiroetsa (<10%).
Deduction
Unlike nitrofurantoin (furadonina), after the adoption of Furamaga® Urine pH is not changed. Through 4 hours after ingestion furazidina concentration in urine concentration significantly exceeds that, which is formed after administration of the same dose furagin.
Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially exposed to the back of reabsorption in the tubules. At low concentrations of furazidin in the urine, the process of filtration and secretion predominates, at high concentrations, decreases the secretion and increases the reabsorption. Furazidin, Being a weak acid in acidic urine does not dissociate, Under intense reabsorption, that can enhance the development of systemic side effects. When alkaline urine excretion furazidina enhanced.
Pharmacokinetics in special clinical situations
By reducing the renal excretory function metabolic rate increases.
Furamag: testimony
Infection, caused by susceptible microorganisms:
- urogenital infections (acute cystitis, uretrity, pyelonephritis);
- gynecological infections;
- infections of skin and soft tissue;
- severe infected burns;
- for prophylactic purposes in urological operations (incl. cystoscopy, Catheterization).
Furamag: dosing regimen
The drug is taken orally after a meal.
Adults appoint 50-100 mg 3 times / day.
Children over 3 years appoint 25-50 mg (no more 5 mg / kg body weight) 3 times / day.
A course of treatment 7-10 days. If you need to repeat the course of treatment should take a break for a 10-15 days.
To prevention of infection (incl. urological operations, cystoscopy, Catheterization) drug prescribed adult by 50 mg, children – by 25 mg dose of 30 minutes prior to the procedure.
In the event of missed doses, next dose should be taken at the usual time. Do not take double the dose to compensate the missed dose.
Furamag: side effects
From the digestive system: rarely – nausea, vomiting, loss of appetite, abnormal liver function.
From the central and peripheral nervous system: rarely – headache, dizziness, polyneuritis.
Allergic reactions: rarely – skin rash (incl. papular rash).
Furamag® malotoksichen.
Furamag: Contraindications
- severe chronic renal failure;
- pregnancy;
- lactation (breast-feeding);
- Children up to age 3 years (for a given dosage form);
- hypersensitivity to drugs of the nitrofuran group.
FROM caution use in patients with deficiency of glucose-6-phosphate dehydrogenase, in the neonatal period.
Furamag: Pregnancy and lactation
Do not use this drug during pregnancy and lactation (breast-feeding).
Furamag: Special instructions
To reduce the risk of side effects Furamag® washed down with plenty of liquid.
When the side effects of the drug should be discontinued (toxic effects often occur in patients with impaired renal excretory function).
The patient must inform the doctor about any side effects, occur during treatment with.
During treatment the patient is recommended to refrain from drinking alcoholic beverages, because side effects may be increased.
Effects on ability to drive vehicles and management mechanisms
Effects on ability to drive vehicles and management mechanisms are not noted.
Furamag: overdose
Symptoms: manifestations of a neurotoxic nature, ataxia, tremor.
Treatment: should drink plenty of fluids. For the relief of acute symptoms used antihistamines (difengidramin). To prevent possible appointment of vitamins neuritis (thiamine bromide).
Furamag: drug interaction
Do not use Furamag® at the same time ristomycin, chloramphenicol, sulьfanilamidami (It increases the risk of bone marrow suppression).
Not recommended together with nitrofurans prescribe drugs, able to acidify the urine (incl. ascorbic acid, calcium chloride).
Furamag: terms of dispensing from pharmacies
The drug is released under the prescription.
Furamag: terms and conditions of storage
The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 3 year.
