FLAGIL

Active material: Metronidazol
When ATH: P01AB01
CCF: Antiprotozoal drug with antibacterial activity
When CSF: 07.01.01
Manufacturer: SANOFI-AVENTIS France (France)

DOSAGE FORM, COMPOSITION AND PACKAGING

Pills, coated from white to pale yellow, round, Engraved “F250” on one side.

Excipients: wheat starch, povidone K30, magnesium stearate, gipromelloza, macrogol 20 000.

10 PC. – blisters (2) – packs cardboard.

Mode of action and pharmacokinetics

Flagyl belongs to the family of nitro-imidazoles 5 and has a broad spectrum of activity against anaerobic microorganisms.

Inhibits the development of protozoa – Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia, Peptostreptococcus, Clostridium sp., Bacteroides sp., Prevotella, Fusobacterium, Veilonella.

When administered Flagyl rapidly and completely absorbed. The half-life is 8-10 sometimes, connection with the blood supply is weak and does not exceed 10-20%.

The drug is rapidly penetrates the tissues (lungs, kidneys, liver, skin, bile, cerebrospinal fluid, spittle, semen, vaginal secretions), in mother's milk and overcomes the placental barrier.

Withdrawal is carried out on 40-70% through the kidneys (about 20% in unmodified form).

Patients with liver failure half-life remains unchanged.

Testimony

The drug is used for

• ameʙiaze,
• urogenital trichomoniasis,
• nonspecific vaginitis,
• giardiasis.

Intravenous administration of the drug is indicated for

• surgical infection,
• caused by susceptible anaerobic him,
• for the prevention of anaerobic infections during surgery,
• as well as severe forms of intestinal and hepatic amoebiasis

Dosage regimen

When used amebiasis in for 7 days 1,5 g per day for three doses (adults) and 30-40 mg / kg per day and for three doses (children). ·

Giardiasis is treated for 5 days – Adults appoint 750-1000 mg per day, children 2-5 years receive 250 mg per day, children 5-10 years – by 375 mg per day, children and 10-15 years – by 500 mg per day.

If trichomoniasis in women (urethritis and vaginitis) Flags are assigned a single dose 2 g or a course of treatment for 10 days: by 1 tab. (250 mg) 2 twice daily and 1 Vaginal suppozytoryyu (500 mg) in a day.

If trichomoniasis in men (uretrit) Flags are assigned a single dose 2 g or a course of treatment for 10 days 1 tab. (250 mg) 2 once a day.

When nonspecific vaginitis apply 500 Flag mg 2 twice a day for 7 days.

In the treatment of anaerobic infections adults appoint the flag 1-1,5 g per day, children – calculated 20-30 mg / kg per day.

Intravenous drug is indicated only in case of impossibility of reception it any other way, or in severe forms of disease. 100 ml (500 mg) administered for 30-60 minutes.

Side effect

In rare cases nausea, metallic taste in mouth, anorexia, epigastric pain, vomiting, diarrhea, headache and dizziness, and local skin reactions such as urticaria and pruritus.

Prolonged treatment with high doses can occur leukopenia, perifericheskie neuropathy, who always regress when discontinuing treatment.

Perhaps the appearance of a brown-reddish color of urine due to the presence of pigments, related to the metabolism of the flag.

Contraindications

• Hypersensitivity to imidazoles.

We do not recommend the use of the flag in nursing mothers.

Pregnancy and lactation

These are not represented.

Cautions

It is undesirable combination of flags with disulfiram (Esperal), anticoagulants indirect action (warfarin) and non-depolarizing muscle relaxants (vekuronium).

Drinking alcohol is contraindicated.

The level of lithium in the blood plasma can be increased when taken with lithium Flag.

Care should be taken when used during pregnancy.

Long-term administration of the drug, it is desirable to carry out under the control of blood formula.

At leucopenia the possibility of extending the treatment depends on the danger of infection. Discontinue treatment should be the appearance of ataxia, dizziness, the deterioration of neurological status of patients.

It should be taken into account, metronidazole may immobilize Treponema, which leads to false positive test Nelson

Overdose

These are not represented.

Drug Interactions

It enhances the effect of indirect anticoagulants, which leads to an increase in the formation of prothrombin time. Similarly, disulfiram causes intolerance to ethanol.

The simultaneous use of disulfiram can lead to a variety of neurological symptoms (the interval between administration – no less 2 Sun). Metronidazole for i / v introduction is not recommended to mix with others. PM. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the serum and an increased risk of side effects.

Co-administration of drugs, stimulating enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin), may accelerate the elimination of metronidazole, resulting in lowered plasma concentration.

When concomitantly with drugs Li may increase concentration in plasma and the development of symptoms of intoxication.

Do not combine with non-depolarizing muscle relaxants (vekuroniya bromide).

Sulfonamide enhance antimicrobial effects of metronidazole.

Conditions and terms

Store at room temperature.

Shelf life : 5 years

Keep out of reach of children.