FERVEKS

Active material: Vitamin C, Paracetamol, Pheniramine
When ATH: N02BE51
CCF: The drug for the symptomatic treatment of acute respiratory diseases
ICD-10 codes (testimony): J00, J06.9, J10
At KFU: 03.02.01.03
Manufacturer: BRISTOL-MYERS SQUIBB (France)

Pharmaceutical form, composition and packaging

◊ Powder for oral solution lemon light beige color, with a characteristic odor; allowed blotches of brown.

Excipients: mannitol, Citric acid anhydrous, povidone, trimagnesium dicitratobismuthate Anhydrous, Aspartame, lemon rum flavoring (Antilles).

4.95 g – packets of the composite material (6) – packs cardboard.
4.95 g – packets of the composite material (8) – packs cardboard.
4.95 g – packets of the composite material (12) – packs cardboard.
4.95 g – packets of the composite material (16) – packs cardboard.

◊ Powder for oral solution lemon with sugar light beige color, with a characteristic odor; allowed blotches of brown.

Excipients: sucrose, Citric acid anhydrous, acacia, soluble saccharin, lemon rum flavoring (Antilles).

13.1 g – packets of the composite material (6) – packs cardboard.
13.1 g – packets of the composite material (8) – packs cardboard.

◊ Powder for oral solution raspberry sugar from light pink to light beige color; allowed blotches of dark pink.

Excipients: sucrose, Citric acid anhydrous, acacia, sodium saccharin, raspberry flavor.

12.75 g – packets of the composite material (4) – packs cardboard.
12.75 g – packets of the composite material (5) – packs cardboard.
12.75 g – packets of the composite material (6) – packs cardboard.
12.75 g – packets of the composite material (8) – packs cardboard.

Pharmacological action

Combined preparation for the symptomatic treatment of acute respiratory infections.

Paracetamol - analygetik-antipyretic, It has analgesic and antipyretic action, due from its influence on the thermoregulation center in the hypothalamus; eliminates headache and other types of pain, reduces fever.

Vitamin C (vitamin C) involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of corticosteroids, collagen and procollagen; normalizes capillary permeability. Increases resistance, which is associated with stimulation of the immune system.

Pheniramine – gistaminovыh blocker H₁-receptors, reduces rhinorrhea, a feeling of nasal congestion, sneezing, lacrimation, itchiness and redness of the eyes.

Pharmacokinetics

Data on the pharmacokinetics Fervex not provided.

Testimony

- SARS (simptomaticheskaya therapy);

- Rinofaringit.

Dosage regimen

Fervex appointed interior 1 paketiku 2-3 times / day. preferably between meals. The interval between doses of the drug is not less than 4 no.

In patients with impaired liver or kidney function and elderly patients interval between doses of the drug should be at least 8 no.

Length of treatment (without consulting your doctor) is less than 5 days, when used as an analgesic agent and more 3 days – as an antipyretic.

The drug should be completely dissolved in a glass of warm water and the resulting solution immediately drink.

Side effect

From the digestive system: nausea, epigastric pain; rarely – dry mouth; long-term use at doses, greatly exceeding the recommended, It increases the likelihood of liver function abnormalities.

From the hematopoietic system: rarely – anemia, thrombocytopenia, metgemoglobinemiâ.

From the urinary system: rarely – urinary retention; long-term use at doses, greatly exceeding the recommended, It increases the likelihood of renal impairment.

Allergic reactions: skin rash, itch, hives, angioedema.

Other: rarely – Parez akkomodacii, drowsiness.

The drug was well tolerated at recommended doses.

Contraindications

- Erosive and ulcerative lesions of the gastrointestinal tract (exacerbation);

- Renal failure;

- Portal hypertension;

- Alcoholism;

- Deficiency of glucose-6-fosfatdegidrogenazы;

- Children up to age 15 years;

- I and III trimesters of pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

FROM caution use in patients with hepatic insufficiency, angle-closure glaucoma, prostatic hyperplasia, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), in viral hepatitis, alcoholic hepatitis, in elderly patients.

Pregnancy and lactation

Do not use this drug in I and III trimesters of pregnancy and lactation (breast-feeding).

Cautions

If you want to receive metoclopramide, domperidone or cholestyramine during use Fervex patient should consult a doctor.

During the application Fervex possible distortions in the laboratory studies the quantitative determination of the concentration of uric acid and plasma glucose.

To avoid liver toxicity of paracetamol should not be combined with alcohol, and to take persons, prone to chronic alcohol consumption.

Using the drug the risk of liver damage increases in patients with alcoholic hepatosis.

With prolonged use at dosages, greatly exceeding the recommended, necessary to monitor patterns of peripheral blood.

Use in patients with diabetes

The drug is in the form of powder for oral solution contains lemon and sugar can be used in patients with diabetes.

IN 1 bag of the drug in the form of powder for oral solution with sugar or lemon raspberry sugar contained 11.5 g sugar, corresponding 0.9 HE. This should be considered, if necessary, the application of this formulation in diabetic patients or in patients, I am on a diet with a reduced sugar content.

Overdose

Symptoms are caused by the action of paracetamol: pale skin, decreased appetite, nausea, vomiting; gepatonekroz (the severity of necrosis due to intoxication is directly dependent on the extent of overdose). Toxic effects in adults may, after receiving a dose of paracetamol 10-15 g: increase in liver transaminases, increased prothrombin time (through 12-48 h after administration); a full-blown liver disease manifests itself through 1-6 days. Rarely – fulminant hepatic failure, which may be complicated by renal failure (tubular necrosis).

Treatment: first 6 h after overdose – gastric lavage, introduction of donators SH-groups and precursors of glutathione synthesis – through methionine 8-9 hours after the overdose and N-acetylcysteine ​​after 12 no. The need for additional therapeutic interventions (further introduction of methionine, a / introduction of N-acetylcysteine) determined by the concentration of paracetamol in the blood, as well as the time, since his admission.

Drug Interactions

Antidepressants, antiparkinsonian agents, antipsychotics (phenothiazines) – increase the risk of side effects (urinary retention, dry mouth, constipation) Ferveksa.

At simultaneous application with Valium Fervex increase the risk of glaucoma.

Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes the possibility of severe intoxication with small overdoses of the drug.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxicity of paracetamol.

Paracetamol reduces the effectiveness of drugs urikozuricheskih.

Ethanol contributes to the development of acute pancreatitis.

Ethanol enhances the sedative effect of antihistamines.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children, dry place at temperatures no higher than 25 ° C. Shelf life – 3 year.