Pheniramine

When ATH:
R06AB05

Pharmacological action

Gistaminovыh blocker H₁-receptors. It has anti-allergic effect, reduces the phenomenon of exudation. When administered the therapeutic effect occurs during 1 hours and continues until 24 no.

Pharmacokinetics

After oral administration, C_max plasma levels achieved after 1-2.5 no. T_1/2 in the final phase of 16-19 no. Excreted in the urine (70-83%) in the form of unchanged substance and metabolite.

Testimony

Pollen disease (hay fever), allergic rhinitis, konъyunktyvytы; neurodermatitis; itching of various etiologies; angioedema, hives, insect bites, drug dermatitis, thermal burns of I degree; malaise due to radiation therapy.

Dosage regimen

Individual. The average single dose at intake for adults is 25 mg, for teens 12-15 years – 12.75 mg, the multiplicity of reception – 2-3 times / day. The maximum daily dose – 3 mg / kg. The average single dose for i / m administration for adults and adolescents – 45.5 mg, multiplicity of introduction – 1-2 times / day.

The average single dose for children 1-2 years – 7.5 mg, 4-12 years – 15 mg. Multiplicity of reception – 2-3 times / day. Do not take on an empty stomach.

Side effect

Rarely – decrease in the rate of psychomotor reactions, feeling tired, drowsiness, dry mouth, dyspeptic symptoms, tachycardia, urinary retention, allergic reactions, dermatitis, increased intraocular pressure in patients with angle-closure glaucoma; in some cases, especially in children, at a high dose can sense anxiety, excitation, hallucinations, confusion.

Contraindications

Prostatauxe, zakrыtougolynaya glaucoma, Hypersensitivity to pheniramine.

Cautions

In the period of treatment must be monitored by an ophthalmologist.

When pregnancy (especially in the I trimester) and lactation pheniramine used only on strict conditions.

When outpatient treatment should take into account a possible reduction in the rate of psychomotor reactions.

While the use of tranquilizers, hypnotics, MAO inhibitors, Alcohol may increase depressant effects on the central nervous system.

Drug Interactions

Pheniramine potentiates the effect of drugs, CNS depressants (MAO inhibitors, tricyclic antidepressants, antiparkinsonian agents, barbiturates, trankvilizatorы, drugs), and alcohol.

Pheniramine can inhibit the action of anticoagulants and interact with progesterone, reserpine, thiazide diuretics.

Concomitant use of oral contraceptives can reduce the effectiveness of antihistamine component.