Phencarolum

Active material: Xifenadin
When ATH: R06A
CCF: Gistaminovыh blocker H₁-receptors. Allergy medication
When CSF: 13.01.01.01
Manufacturer: OLINEFARM AS (Latvia)

DOSAGE FORM, STRUCTURE AND PACKAGING

◊Pills white or nearly white, round, Valium, chamfered.

Excipients: sugar, potato starch, calcium stearate.

10 PC. – packings Valium planimetric (2) – packs cardboard.

◊ Pills white or nearly white, round, Valium, chamfered.

Excipients: sugar, potato starch, calcium stearate.

10 PC. – packings Valium planimetric (2) – packs cardboard.

Pharmacological action

Fenkarol is derived hinuklidilkarbinola, reduces the effects of histamine on: bodies and their systems. Fenkarol is a competitive blocker of H1 – receptors. Besides, Unlike classical drugs in this group, it activates the enzyme diamine oxidase, which breaks down to 30% endogenous histamine. This explains the effectiveness of Phencarolum patients, resistant to other antihistamines. Fenkarol not penetrate the blood-brain barrier and has little effect on the processes of deamination of serotonin in the brain, slightly affects the activity of monoamine oxidase. Protivogistaminnye Phencarolum properties associated with the presence of quinuclidine core cyclic structure and the distance between the group and the nitrogen atom difenilkarbinola. By protivogistaminnoy activity and duration of action exceeds Phencarolum diphenhydramine. Fenkarol reduces the toxic effect of histamine, It eliminates or reduces its bronchoconstrictor action and spazmiruyutsya effect on the smooth muscles of the intestine, protivoserotoninnym has a moderate and weak cholinolytic, pronounced antipruritic and desensitizing properties. Fenkarol weaken hypotensive effect of histamine and its effects on the permeability of capillaries. Fenkarol has no direct effect on cardiac function and blood pressure. Fenkarol does not have a protective effect in akonitinovyh arrhythmias. Unlike diphenhydramine (dimedrola) and diprazina (pipolfen) Phencarolum not have a depressing effect on the central nervous system, but individual sensitivity is possible weak sedation. The drug is small and lipophilic, compared with dimedrolom and other central nervous system depressants gistaminoblokiruyuschimi means, its concentration in brain tissue is low (less 0,05%), which explains the lack of inhibitory effect on the central nervous system.

Pharmacokinetics

Fenkarol rapidly absorbed from the gastrointestinal tract, and after 30 minutes of drug found in the tissues of the organism. The maximum concentration is reached after an hour.
The metabolites and unchanged share Phencarolum mainly excreted in the urine and bile within 48 hours.

Indications

Pollinosis, food and drug allergy, other allergic diseases, acute and chronic urticaria, edema (angioneurotic) Kvinkle, hay fever, allergic rinopatiya, dermatosis (eczema, psoriasis, neurodermatitis, itching), as well as non-infectious, allergic reactions to the bronchospastic component.

Mode of application

Fenkarol taken orally immediately after meals. Single dose for adults – by 25-50 mg 3-4 once a day. When pollinozah daily dosage less 75 mg ineffective. The maximum daily dose is 200 mg. Duration of treatment 10-20 days.
Children up 3 years – by 5 mg 2-3 once a day; from 3 to 7 years – by 10 mg 2 once a day; from 7 to 12 years – by 10 – 15 mg 2-3 once a day; senior 12 years – by 25 mg 2-3 once a day. The recommended daily dose can be administered in 4 admission. The duration of treatment is 10-15 days.
If time has not been accepted yet another dose, should continue to be treated in a previously assigned doses. If necessary, consult your doctor.

Side effects

If you are sensitive or Phencarolum overdose may occur mild dryness of mucous membranes of the oral cavity, dyspeptic symptoms, which usually are in dose reduction or drug discontinuation. In patients with diseases of the gastrointestinal tract increases the possibility of side effects.
If there were side effects, especially those, which are not specified in the instruction, you must inform the doctor.

Contraindications

1. Individual intolerance to the drug.
2. The first three months of pregnancy.

Pregnancy

Fenkarol protivopakazano for consumption in the first three months of pregnancy.

Interaction with other drugs

Fenkarol not dampening effect of alcohol and sleeping pills on the central nervous system. Fenkarol has weak M-anticholinergic properties, but with a decrease in motility of the gastrointestinal tract absorption slowly absorbs medicines may be increased (eg, antykoahulyantы indirect actions – kumarinы).

Overdose

The daily dose of up to 300 mg causes clinically serious side effects. Large doses may cause dryness of mucous membranes, Headache, vomiting, epigastric pain and other dyspeptic symptoms.

Product form

The tablets of 25 mg, in a package of 20 tablets.

Storage conditions

List B. Store in a dry, protected from light, reach of children. Do not take the medication after the expiration date.
Conditions of supply of pharmacies – without a prescription.