Xifenadin

When ATH:
R06A

Pharmacological action

Histamine H1-receptor. Besides, уменьшает содержание гистамина в тканях за счет активации диаминоксидазы – фермента, inaktiviruyushyego histamine. Has antiallergic, antipruritic and antiexudative action. There has Adreno- and anticholinergic activity. Virtually no sedative and hypnotic action.

Pharmacokinetics

It has low lipophilicity. Poor penetrate the BBB.

Testimony

Pollen disease, nasal allergy, acute and chronic urticaria, angioedema, itching, neurodermatitis, eczema, allergic reactions, associated with taking drugs or food.

Dosage regimen

Взрослым внутрь – по 25-50 mg 3-4 The course of treatment averages 10-20 days. If necessary, repeat the treatment.

Максимальная доза для взрослых – 200 mg /

Children under 3 years - by 5 mg 2-3, aged 3-7 years - by 10-15 mg 2-3

Side effect

From the digestive system: редко – диспептические симптомы, incl. dry mouth.

Contraindications

Hypersensitivity to hifenadina.

Pregnancy and lactation

Not recommended during pregnancy, especially in the I trimester. If necessary, use during lactation should decide the issue of termination of breastfeeding.

Cautions

Caution should be used in diseases of the cardiovascular system, gastric ulcer and duodenal ulcer, expressed violations of the liver and kidneys.

Effects on ability to drive vehicles and management mechanisms

Given the possibility of individual sensitivity, should be used with caution in patients, engage in potentially hazardous activities, requiring a high rate of psychomotor reactions. Recommended prior systemic treatment set, Do not observed in a patient after taking sedatives or hypnotics hifenadina action.