Enterofuril
Active material: Nifuroksazid
When ATH: A07AX03
CCF: Intestinal antiseptics. Antidiarrheal medication
ICD-10 codes (testimony): A09
When CSF: 06.20.02
Manufacturer: BOSNALIJEK d.d. (Bosnia and Herzegovina)
PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING
Capsules hard gelatin, size №0, yellow color, opaque; contents of capsules – Yellow powder or powder inclusions in the form of small pieces of compressed or compacted powder mass, which crumbles under slight pressure.
| 1 caps. | |
| nifuroksazid | 100 mg |
Excipients: sucrose, corn starch, cellulose powder, magnesium stearate.
Ingredients of the capsule shell: titanium dioxide C.I. 77891 (E171), quinoline yellow C.I. 47005 (E104), orange yellow C.I. 15987 (E110), painful C.I. 14720 (E122), Kosin red C.I. 16255 (E124), gelatin.
10 PC. – blisters (3) – packs cardboard.
Capsules hard gelatin, size №0, yellow color, opaque; contents of capsules – Yellow powder or powder inclusions in the form of small pieces of compressed or compacted powder mass, which crumbles under slight pressure.
| 1 caps. | |
| nifuroksazid | 200 mg |
Excipients: sucrose, corn starch, cellulose powder, magnesium stearate.
Ingredients of the capsule shell: titanium dioxide C.I. 77891 (E171), quinoline yellow C.I. 47005 (E104), painful C.I. 14720 (E122), Kosin red C.I. 16255 (E124), gelatin.
8 PC. – blisters (2) – packs cardboard.
8 PC. – blisters (4) – packs cardboard.
Oral suspension thick, yellow color, with the smell of banana.
| 5 ml | |
| nifuroksazid | 200 mg |
Excipients: sucrose, Sodium hydroxide, metilparagidroksiʙenzoat, ethanol 96%, karʙomer, lemon acid, Banana flavor, water distillirovannaya.
90 ml – vials of dark glass volume 100 ml (1) complete with a scoop – packs cardboard.
Pharmacological action
Antimicrobial wide spectrum of action for the treatment of gastrointestinal infections, the 5-nitrofuran. Expected, that antimicrobial and antiparasitic effect is due to the presence in the nifuroxazide NO2-groups, which acts on the cage pathogen.
It is active against Gram-positive microbein: Staphylococcus pyogenes, Streptococcus pyogenes, Clostridium spp.; Gram-negative enterobacteria: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Yersinia spp., Citrobacter spp., Campylobacter spp., Edwarsiella spp.
No effect on saprophytic flora, It does not violate the balance of normal intestinal flora.
Pharmacokinetics
After taking the drug inside nifuroxazide virtually not absorbed from the gastrointestinal tract, showing their antibacterial activity only in the intestinal lumen. Fully excreted in the feces. The elimination rate depends on both the dose, and on gastrointestinal motility.
Testimony
- Acute and chronic diarrhea of infectious origin (without evidence of helminthic invasion).
Dosage regimen
Adults and children over 7 years the drug is prescribed for 200 mg 4 times / day, daily dose – 800 mg; Children from 2 to 7 years – by 200 mg 3 times / day, daily dose – 600 mg.
Children under the age of 2 years drug administered only in the form of suspensions. To use the dispensing scoop. To children aged 7 months before 2 years The recommended dose is 100 mg (2.5 ml or 1/2 measuring spoon) 4 times / day, children aged 1 to 6 months – 100 mg (2.5 ml or 1/2 measuring spoon) 2-3 times / day. Before applying the suspension is necessary to mix well.
Duration of therapy should not exceed 7 days.
Side effect
Maybe: allergic reactions.
Contraindications
- Up to 1 of the month, preterm infants;
- Hypersensitivity to derivatives of nitrofuran.
Pregnancy and lactation
Can be used during pregnancy and lactation on the testimony.
Cautions
In the treatment of diarrhea while using Enterofuril should be rehydration therapy (in / or oral) in accordance with the condition of the patient and the degree of dehydration.
Against the background of Enterofuril forbidden to drink alcohol.
Overdose
No specific symptoms of overdose.
Treatment: if necessary, symptomatic therapy.
Drug Interactions
To date, drug interactions of the drug is not described Enterofuril.
Conditions of supply of pharmacies
The drug is resolved to application as an agent Valium holidays.
Conditions and terms
The drug should be stored out of reach of children at or above 30 ° C. The suspension does not freeze. Shelf life for capsules – 5 years, suspension for oral – 3 year.
