BUSCOPAN

Active material: Giosцina -in
When ATH: A03BB01
CCF: M-holinoretseptorov Blocker
ICD-10 codes (testimony): K25, K26, K31.3, K80, K81.0, K81.1, K82.8, N23, N94.4, N94.5, R10.4
When CSF: 11.07.01.02
Manufacturer: BOEHRINGER INGELHEIM INTERNATIONAL GmbH (Germany)

Pharmaceutical form, composition and packaging

◊ Pills, coated (sugar) white, round, lenticular, with an almost imperceptible odor.

Excipients: calcium hydrogen phosphate (calcium hydrogen phosphate anhydrous), dried corn starch, potato starch digested (soluble starch), colloidal silicon dioxide, tartaric acid, stearic acid.

The composition of the shell: povidone (polyvinylpyrrolidone), sucrose, talc, acacia gum (acacia), Titanium dioxide, macrogol 6000 (polyethylene glycol 6000), carnauba wax, beeswax white (white wax).

10 PC. – blisters (1) – packs cardboard.
10 PC. – blisters (2) – packs cardboard.
20 PC. – blisters (1) – packs cardboard.
20 PC. – blisters (2) – packs cardboard.

Pharmacological action

M-holinoretseptorov Blocker. Has antispasmodic effect on smooth muscles of internal organs, decreases the secretion of digestive glands. Do not cross the BBB (tk. hyoscine butylbromide is ammonium četvertičnym derived), therefore no antiholinergicescoe effect on the central nervous system.

Pharmacokinetics

Absorption

After ingestion poorly absorbed from the digestive tract.

Distribution

Plasma protein binding is low.

The largest number of active substances are present in the digestive tract, gall bladder and bile ducts, kidney, uterus.

Testimony

— spastical diskinesia biliary tract and gall-bladder (incl. počečnaâ how, želčnaâ how, kišečnaâ how, cholecystitis, pilorospazm);

- Gastric ulcer and duodenal ulcer in the acute phase (in the complex therapy);

- Algomenorrhea.

Dosage regimen

Adults and children over 6 years appointed interior 1-2 tab. 3-5 time / day.

The tablets should be taken orally, drinking water.

Side effect

Side effect, associated with holinoblokirutm effect of the medicine: dry mouth, dry skin, tachycardia; It is possible to urine retention (usually weakly expressed and resolves on its own).

Allergic reactions: rarely – cutaneous manifestations, Anaphylaxis with episodes of wheezing.

Contraindications

-myasthenia gravis;

- Megacolon;

- Children up to age 6 years;

- Hypersensitivity to the drug.

Pregnancy and lactation

Use of the drug during pregnancy and lactation (breast-feeding) possibly only, when the intended benefits to the mother outweighs the potential risk to the fetus or infant.

Cautions

Be wary appoint the drug with suspected intestinal obstruction (incl. stenosis pryvratnyka), When obstruction of the urinary tract (incl. prostate adenoma), the propensity to tahiaritmii (incl. atrial fibrillation), angle-closure glaucoma.

Tablet Buskopana^® It contains 41.2 Sucrose mg. The maximum recommended daily dose contains 411.8 Sucrose mg.

Overdose

Currently, the cases of drug overdose Buscopan not described, Therefore, the following symptoms and recommendations are theoretical.

Symptoms: possible anticholinergic effects – urinary retention, dry mouth, erythema, tachycardia, inhibition of GASTROINTESTINAL motility, transient visual disturbances.

Treatment: gastric lavage, activated carbon, and then 15% a solution of magnesium sulfate. Further demonstrates the use of holinomimetikov. When glaucoma locally appointed pilocarpine (as eyedrops). If necessary, designate holinomimetiki for systemic use (eg, give/m or/in the dose of neostigmine 0.5-2.5 mg); cardiovascular complications are treated according to the usual therapeutic rules; carry out supportive and symptomatic therapy; When paralysis of respiratory muscles – Intubation and MECHANICAL VENTILATION; urine retention – bladder catheterization.

Drug Interactions

Buscopan^® can increase antiholinergicescoe effect tricyclic antidepressants, antihistamines, xinidina, amantadina, dizopiramida, anticholinergic drugs (eg, tiotropium bromide, ipratropiya bromide).

Simultaneous application Buskopana^® and dopamine antagonists (eg, metoclopramide) leads to a weakening of the actions on the INTESTINE of both drugs.

Buscopan^® It may exacerbate the tachycardia, called beta-adrainomimetikami.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C. Shelf life – 5 years.