Bencyclane

When ATH:
C04AX11

Characteristic

Benciklana fumarate is a white odorless crystalline substance. Solubility in water: at 25 °C — 1 g / 100ml, in hot water is 2 g / 100ml. It is soluble in acetone, easy — alcohol. Molecular weight 405,53.

Pharmacological action

Spasmolytic, vasodilator.

Application

Cerebrovascular accidents, cerebrovascular disease and atherosclerotic genesis angiospastic, Eye disease, occlusion of the central retinal artery, diabetic angiopathy, obliterating peripheral arterial disease of various origins, angiodistonii, post-operative and post-traumatic disorders of peripheral blood circulation, variant angina

, gastric ulcer and duodenal ulcer, other gastrointestinal diseases, accompanied by spastic or hypermotor dyskinesia esophagus, stomach, Biliary, bowel, počečnaâ how, spasms of the urinary tract, bronchial obstruction.

Contraindications

Hypersensitivity, renal failure, expressed human liver, respiratory insufficiency, paroxysmal supraventricular or ventricular acute takikardiya, taxiaritmii, pregnancy, lactation.

For injecting is a violation of the functions of the cardiovascular system, respiratory disorders, tendency to collapse, urinary retention, associated with prostatic hypertrophy.

Side effects

Dizziness, headache, generalized weakness, excitation, sleep disorders, tremor, epileptiform symptoms, hallucinations (in elderly patients), dry mouth, nausea, loss of appetite, diarrhea, transient increase in liver transaminases, tachycardia, leukopenia, allergic reactions. In case of contact solution under the skin there is local inflammatory tissue reaction.

Cooperation

Enhances deprimatsiyu, caused by anesthetic and sedative. Increases the risk of tachyarrhythmias in the background sympathomimetic and heart disorders under the influence of drugs kaliyvyvodyaschih (Diuretic, corticosteroids).

Overdose

Symptoms: renal failure and liver, psychomotor agitation.

Treatment: symptomatic.

Dosing and Administration

Inside — for 100-200 mg 1-2 times a day for 3-4 weeks, then - on 100 mg 2 once a day (maintenance therapy); The maximum daily dose - 400 mg.

In acute and severe disease prescribe parenterally — for 50-100 mg 1-2 times a day, in / slow bolus (in saline) or/m is on 50 mg 1-2 times a day.

Precautions

For parenteral administration, it is recommended to change the injection sites (to prevent thrombophlebitis). With prolonged use is necessary to conduct systematic monitoring of liver function and blood count. When concomitant administration with drugs, cause hypokalemia, cardiac glycosides, kardiodepressantami, daily dose should not exceed 150-200 mg. Be wary appointed in conjunction with the means, weaken the force of heart contractions (beta-blockers, quinidine). Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.