Ademethionine

When ATH:
A16AA02

Characteristic.

A derivative of methionine. Lyophilized white powder.

Pharmacological action.
Gepatoprotektivnoe, antidepressant, detoxifying, stimulatory regeneration, antioksidantnoe, neuroprotective.

Application.

Intrahepatic cholestasis, liver disease: toxic, including alcoholic, Viral, Medicinal (antibiotics, antineoplastic, TB, antivirals, tricyclic antidepressants, oral contraceptives); cirrhotic and pretsirroticheskie state; encephalopathy, incl. associated with liver failure (Alcoholic and others.); depression and withdrawal symptoms.

Contraindications.

Hypersensitivity, pregnancy (I and II trimesters).

Restrictions apply.

Childhood (safety and effectiveness in children have not identified).

Pregnancy and breast-feeding.

Contraindicated in pregnancy (I and II trimesters). At the time of treatment should stop breastfeeding.

Side effects.

From the digestive tract: ingestion - heartburn, pain or discomfort in the epigastric region, dyspepsia.

Other: allergic reactions.

Dosing and Administration.

Inside, without chewing, between meals, preferably in the first half of the day; / m or I / (very slow); Only the powder is dissolved in a special solvent supplied (solution of L-lysine). Adults: intensive care - a / m or / by 400-800 mg / day (the contents of the vials 1-2) during the first 2-3 weeks, then inside (maintenance therapy) at 800-1600 mg / day (2Table -4.) during 2 Months.

Precautions.

Considering tonic effect, not recommended before bedtime. Treatment is carried out under the supervision of a physician. During long-term therapy is necessary to determine the content of urea and serum creatinine. When cirrhotic and pretsirroticheskih states on background hyperasotemia should carefully monitor the level of nitrogen in the blood.

Cautions.

The solution is prepared immediately before use; tablet is removed from the packaging before taking. If you change the color of a lyophilized powder or tablets should refrain from using them.

Cooperation

Active substanceDescription of interaction
ClomipramineFMR.Against the background of ademetionine increases the likelihood of developing serotonin syndrome (excitation, confusion, stupor, tachycardia, hurried breathing, diarrhea, myoclonus, generalized tremors, rigidity, hyperreflexia, tremor, profuse pototdelenie, degidratatsiya, to hyperthermia 43 °C); combined use requires caution.

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