Coldrex Hawtrey

Active material: Vitamin C, Paracetamol, Phenylephrine
When ATH: N02BE51
CCF: The drug for the symptomatic treatment of acute respiratory diseases
ICD-10 codes (testimony): J06.9, J10, R50
At KFU: 03.02.01.03
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)

Pharmaceutical form, composition and packaging

◊ Powder for oral solution crystalline, from pale yellow to yellow, with a characteristic odor of lemon, powder is dissolved in hot water to form yellow solution with a characteristic smell of lemon.

Excipients: lemon acid, sodium saccharin, sodium citrate, sucrose (3 g), flavor lemon tetrarom 100%, lemon flavor, quinoline yellow.

5 g – bags (5) – packs cardboard.
5 g – bags (10) – packs cardboard.
5 g – bags (50) – packs cardboard.

◊ Powder for oral solution crystalline, purple, with a characteristic smell of blackcurrant, powder is dissolved in hot water with the formation of the purple Grout with a characteristic smell of blackcurrant.

Excipients: Citric acid anhydrous, sodium saccharin, sodium citrate, sucrose (3 g), Flavors (Tutti Frutti, crimson,blackcurrant), food dye blackcurrant Hexacol.

5 g – bags (5) – packs cardboard.
5 g – bags (10) – packs cardboard.
5 g – bags (50) – packs cardboard.

Pharmacological action

Combined preparation for the symptomatic treatment of acute respiratory infections.

Paracetamol okazыvaet zharoponizhayushtee, analgesic effect.

Phenylephrine hydrochloride – sympathomimetic, It constricts blood vessels of the mucous membranes of the nose and paranasal sinuses, thereby reducing the swelling and nasal breathing easier.

Ascorbic acid compensates for the increased need for vitamin C for colds and flu, especially in the initial stages of the disease.

Active components of the drug does not cause drowsiness and do not violate the concentration.

Pharmacokinetics

The data on the pharmacokinetics Coldrex^® HotRem not available.

Testimony

To eliminate the symptoms of acute respiratory infections and influenza, including:

-fever (increase in body temperature);

- Headache;

- Chills;

- Pain in joints and muscles;

- Nasal congestion;

-pain in the throat and in the sinuses of the nose.

Dosage regimen

Adults recommend taking on 1 Every sachet 4-6 no, but not more 4 bags for 24 no. The interval between doses should be at least 4 no.

Children over 12 years appoint 1 Every sachet 6 no, but not more 3 bags for 24 no.

Contents 1 bags need to be emptied into a glass of hot water (200 ml), stir until dissolved, Optionally, you can add cold water or sugar.

The maximum duration of the drug – 5 days.

Side effect

Side effects, caused part of the drug paracetamol.

Allergic reactions: skin rash, hives, angioedema.

From the hematopoietic system: rarely – thrombocytopenia, leukopenia, agranulocytosis.

Prolonged use in excess of the recommended dose can be observed hepatotoxicity and nephrotoxicity.

Side effects, caused part of the drug phenylephrine.

Cardio-vascular system: a slight increase in blood pressure; rarely – heartbeat.

Other: nausea, headache.

Contraindications

- Expressed human liver;

- Expressed by the human kidney;

- Thyrotoxicosis;

- Diabetes;

-hereditary sugar malabsorption;

- Heart disease (marked aortic stenosis, acute myocardial infarction, taxiaritmii);

- Arterial hypertension;

- Concomitant use of tricyclic antidepressants, beta-blockers, MAO inhibitors and the period up to 14 days after their cancellation;

-simultaneous other paracetamol-containing funds and for relief of symptoms of colds and flu;

-Prostate hypertrophy;

- Zakrыtougolynaya glaucoma;

- Children up to age 12 years;

- Hypersensitivity to the drug.

FROM caution the preparation should be applied to genetic lack of glukozo-6-fosfatdegidrogenaza, in benign giperbilirubinemiâh.

Pregnancy and lactation

The drug should be used with caution during pregnancy and breastfeeding.

Cautions

The patient should be informed, if symptoms persist after 5 days of the drug, should stop taking it and consult a doctor.

The drug should only be taken in recommended doses.

Precautions should be taken Coldrex^® HotRem simultaneously with metoklopramidom, domperidone, kolestiraminom and indirect antikoagulyantami (warfarin).

Patients, receiving the drug Coldrex^® HotRem, should refrain from drinking alcohol. Not recommended to prescribe the drug for alcoholism.

Patients, diet with low-sodium, should be considered, what 1 bag Koldreksa^® HotRem contains the 0.12 g of sodium.

Effects on ability to drive vehicles and management mechanisms

Because the active components of the drug have no sedative effect, When taken in recommended doses, restrictions on driving and working with the mechanisms no.

Overdose

In the case of drug overdose Coldrex^® HotRem (even if the well-being) should take into account the risk of delayed signs of serious liver damage.

Symptoms: pale skin, nausea, vomiting, anorexia, necrosis of hepatocytes, increase in liver transaminases, increased prothrombin time.

Treatment: gastric lavage, followed by the appointment of activated charcoal; if necessary, symptomatic therapy. A specific antidote for acetaminophen poisoning is NAC.

Drug Interactions

In case of simultaneous use of barbiturates, difenina, karʙamazepina, rifampicin, zidovudine and other induction mikrosomaionah liver enzymes with Koldreksom^® HotRem increases the risk of hepatotoxic action.

Coldrex^® HotRem enhances the effects of MAO inhibitors, sedation and ethanol.

Together with the application Koldreksom^® HotRem antidepressants, antiparkinsonian, antipsychotics, derived fenotiazina increases the risk of urinary retention, dry mouth, constipation.

Joint application with GKS increases the risk of glaucoma.

Paracetamol reduces the efficacy of diuretics.

Simultaneous use of the drug with galotanom increases the risk of ventricular arrhythmia.

Phenylephrine reduce the hypotensive effect of guanethidine.

Guanethidine increases Alpha-adrenostimuliruûŝij, and tricyclic antidepressants – simpatomimeticeski effect of phenylephrine.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C. Shelf life - 3 year.