Paracetamol: instructions for using the medicine, structure, Contraindications

When ATH: N02BE01

Title: Paracetamol (Paracetamolum)

Paracetamol: pharmachologic effect

Paracetamol obladaet zharoponizhayushtim, analgesic and moderately anti-inflammatory properties. Inhibits the excitability of the thermoregulatory center, also inhibits (oppresses) synthesis of prostaglandins, inflammatory mediators with a pronounced organic effect.

Paracetamol is rapidly absorbed from the upper intestine, It penetrates into all tissues of the body, metabolised in the liver, with the formation of glucorangide and paracetamol sulfate, excreted mainly by the kidneys. A small amount of paracetamol is deacetylated to form para-aminophenol, which promotes the formation of methemoglobin, this leads to drug toxicity.. The binding of paracetamol to plasma proteins is 25%. The maximum concentration of the drug when administered orally is observed through 30-40 minutes. The antipyretic effect comes through 1,5-2 o'clock. half-life of paracetamol 2-4 o'clock.

With prolonged use of paracetamol in high doses, the drug may have a hepatotoxic effect.

Paracetamol: Indications for use

Paracetamol is indicated for the symptomatic treatment of pain syndrome of various origins of mild to moderate intensity.: headache, toothache, algomenorrhea, myalgia, neuralgia, backache, arthralgia, and the state, which are accompanied by a hyperthermic reaction in infectious and inflammatory diseases.

Paracetamol: application method

Paracetamol tablets use

For adults, a single dose of paracetamol is 0,35-0,5 g 3-4 once a day, maximum single dose for adults 1,5 g, the maximum daily dose 3-4 g. The drug should be taken after meals, drinking plenty of water.
For children 9 to 12 years, The maximum daily dose is 2 g.
For children 3 to 6 years, the maximum daily dose 1-2 g paracetamol, calculated 60 mg 1 kg body weight of the child 3-4 admission.

Paracetamol rectal suppositories application

For children aged from 1 months before 3 years use rectal suppositories, single dose of paracetamol is 15 mg 1 kg body weight, daily – 60 mg 1 kg body weight of the child. Multiplicity of use 3-4 once a day.
For adults and adolescents overweight 60 kg, single dose of 0,35-0,5 g, the maximum single dose 1,5 g 3-4 once a day. Daily dose 3-4 g.
For children 6 to 12 years, The maximum daily dose is 2 g 4 admission.
For children 3 to 6 years, the maximum daily dose 1-2 g paracetamol, calculated 60 mg 1 kg body weight of the child 3-4 admission.

paracetamol syrup application

For children aged from 3 to 12 months 2,5-5 ml syrup (60-120 mg paracetamol).
For children 1 Year to 5 years - 5-10 ml syrup (120-240 mg paracetamol).
For children aged from 5 to 12 years - 10-20 ml syrup (240-480 mg paracetamol).
Adults and children overweight 60 kg – 20-40 ml syrup (480-960 mg paracetamol).
The frequency of taking paracetamol syrup is 3-4 once a day.
If the patient's condition has not improved while taking paracetamol, it is necessary to inform the doctor about it.

Side effects of paracetamol

Blood system: anemia, thrombocytopenia, agranulocytosis, leukopenia, metgemoglobinemiâ.
From the excretory system: počečnaâ how, aseptic pyuria, glomerulonephritis.
From the nervous system: increased excitability or vice versa drowsiness.
Cardio-vascular system: decreased contractility of the heart muscle.
On the part of the digestive system: nausea, epigastric pain. With prolonged use of paracetamol in high doses, the drug may have a hepatotoxic effect..
Allergic reactions: skin rashes, itch, angioedema.

Paracetamol contraindications

Hypersensitivity to paracetamol, liver and kidney failure.
When using rectal suppositories, contraindications are inflammatory diseases of the rectal mucosa.

Pregnancy and paracetamol

With caution, paracetamol is prescribed to pregnant women and during lactation..

Paracetamol: drug interaction

With the simultaneous use of barbiturates of antiepileptic drugs, rifampicin may increase the hepatotoxic effect of paracetamol, and also reduces its antipyretic effect. Paracetamol enhances the effect of indirect coagulants (coumarin derivatives). Enhances the action of salicylic acid, caffeine, codeine. When combined with phenobarbital, methemoglobinemia increases. Paracetamol enhances the action of antispasmodics. Do not use paracetamol with other, medicines containing paracetamol, avoid overdose.

Paracetamol: overdose

If the amount of the drug taken is many times higher than the maximum recommended dose, it can cause liver toxicity, accompanied by drowsiness, pale skin and visible mucous membranes, toshnotoy, vomiting and dizziness. Most of these symptoms develop in the first day. If these symptoms appear, you should immediately seek medical help., due to urgent hospitalization. As an antidote use n-acetylcysteine ​​intravenously or orally. Detoxification and symptomatic treatment is also recommended..

Paracetamol: release form

Table. 0,2 g contoured non-cell packing, №10.
Table. 0,2 g strip, №10.
Table. 0.2 g blister, №10.
Paracetamol – 0,2 g.

Table. 325 mg blisters, №6, №12.
Table. 325 mg container, №30.
Paracetamol – 325mg.

Table. 0.5g contoured non-cell packing, №10.
Table. 0,5 g blisters, №10.
Paracetamol – 0,5 g.

Capsules 325 mg blisters, №6, №12.
Capsules 325 mg container №30.

Syrup 125 mg/5ml vial 60 ml, №1.
Syrup 125 mg/5ml vial 100 ml, №1.
Paracetamol – 125mg / 5ml.

Syrup 120 mg/5ml vial 50 ml, №1.
Syrup 120 mg/5ml vial 100 ml, №1.
Syrup 120 mg / 5 ml polymer vial 50 ml, №1.
Syrup 120 mg / 5 ml polymer vial 100 ml, №1.
Syrup 120 mg / 5 ml polymer jar 100 ml, №1.
Paracetamol - 120 mg / 5ml.

Rectal Suppositories 0,08 g strip, №10.
Paracetamol – 0,08 g.

Rectal Suppositories 0,17 g strip, №10.
Paracetamol – 0,17 g.

Rectal Suppositories 0,33 g strip, №10.
Paracetamol – 0,33 g.

Suspension 120 mg / 5 ml vial 100 ml.
Suspension 120 mg/5 ml polyethylene container 200 ml.
Paracetamol – 120 mg / 5 ml.

Paracetamol: storage conditions

Keep out of the reach of children at an air temperature not exceeding 25 degrees Celsius.

Paracetamol Synonyms

Panadol Junior, Tylenol, Ifimol, Aminodol Acetophene, Panadol, Panadol solubl, Opradol, Ushamol, Valadol, Valorin, Acelifen, abesanil, Acetalgin, Actazole, Algotoropil, Aminophen, Dimindol, Dolanex, Dolipram,Apagan, Biocetamol, Celifen, Cetadol, Dapirex, Dolamine, Efferalglan, Erocetamol, Febridol, Pacimol, Pyrenees, Tralgon, Pyremol, Febricet, Calpol, Febrinol, Nasprin, Acemol, Cetanil, Apamide, Acetaminophen, Acetaminophenol, Hemcetafen, Datril, Dexamol, Effered, Febrinil, Fendon, , Myalgin, Napamol, Naprinol, Alvedon, Amphenol, Repeated, Deminofen, Mexican, Apanol, Nizacetol, Rolocin, Tempramol, Volpan, Vinadol, Akamol, Bindard, Paramol, Metamol, I wish, Tilenol, Valgesic, Minoset.
See also the list of analogues of the drug Paracetamol.

Paracetamol: pharmacological group

Painkillers and anti-inflammatory drugs
Non-narcotic analgesics, antipyretic, nonsteroidal anti-inflammatory and antirheumatic drugs. Analgesics-antipyretics.

Active substance: Paracetamol

Paracetamol: additionally

Paracetamol is part of such combination drugs: Paravit for children, Paramin, Parapasta, Para-trawl, Parafex, Pentalgin, Pharmacitron, Fervex, Coldrex, Cold Flu, Ascophene, Tempalgin, Sedalgin-neo, Sedal-M.

Paracetamol interaction