St. John's wort – St. John's wort L.

A perennial herb up to 80 100 see family sealers (Nurepsaseae). It grows like a weed in almost all of the European part of Rosii, the Caucasus, in the mountains of Central Asia and in Western Siberia. For medical purposes harvest the grass plants.

St. John's wort – chemical composition

The herb St. John's wort contains flavonoids (giperozid, rutin, quercitrin, izokvertsitrin and quercetin), fluorescent, coloring and tannins, carotene, gipericin, essential oil, resin, nicotinic and ascorbic acid, vitamin P and PP, mix, anthocyanins, saponins, alcohols, traces of alkaloids and other compounds.

St. John's wort – Pharmacological properties

The herb St. John's wort contains a variety of biologically active compounds and has a versatile pharmacological properties. The most active compounds are flavonoids, has antispasmodic effect on the smooth muscle of the intestinal bile ducts, blood vessels and ureters. Flavonoids increase the flow of bile, prevent stagnation of bile in the gall bladder and thereby prevent the possible formation of stones, facilitate bile into the duodenum by reducing spasm of the sphincter of hepatic, pancreatic ampoule. Flavonoids also cropped spasms of the colon and small intestine, restore normal peristalsis, thereby improving the digestive capacity of the gastrointestinal tract.

St. John's wort is not only relieves spasm of blood vessels, especially capillaries, but the action has kapillyaroukreplyayuschee, typical connections, containing vitamin E. Besides, St. John's wort preparations improve venous circulation and blood supply to some of the internal organs, diuresis and increased by reducing the wall tension ureters and the immediate increase in the renal glomerulus filter.

Tannins plants have a slight astringent and anti-inflammatory effect. They also possess antimicrobial activity against a number of microorganisms, resistance to antibiotics. Bitter substance in water extracts of the herb St. John's wort-ons gastric secretion.

The herb St. John's wort contains hypericin - Connect, chemically similar hematoporphyrin. Hypericin ingestion plays the role of a catalyst of some intracellular reactions and factors, regulating major life processes in the body. Besides, hypericin is a photodynamic agent, boosting the absorption of ultraviolet rays skin, however, it does not dissolve in water, therefore hypericin is not defined in infusions and decoctions, but there are in alcoholic extracts and juice plants.

The high antibacterial activity of essential, alcohol, acetone and other extracts of Hypericum perforatum. They act on Staphylococcus aureus and other bacteria. These data formed the basis for further detailed study of the properties of St. John's wort to obtain new antimicrobials, in particular novoimanina.

Novoimanin was obtained by extracting the herb Hypericum acetone with subsequent removal from the extraction of chlorophyll and other pigments with activated charcoal. With further study novoimanina, is a complex mixture of substances, It was found, that the main active ingredient of this drug is an individual substance, called hyperforin; namely hyperforin inhibits the growth of Staphylococcus aureus.

Giperforin, as novoimanin, It acts on gram-positive microflora in low concentrations. However bakternostatichesky hyperforin effect in some cases considerably higher, than novoimanina. Giperforin, as novoimanin, almost no effect on microorganisms gramotritsatilnye, fungi and actinomycetes. The bactericidal activity of hyperforin and novoimanina significantly lower bacteriostatic. Hyperforin is less toxic, than novoimanin. Despite this, hyperforin has no independent practical significance due to the chemical instability and volatility of antimicrobial activity. Therefore, in medical practice introduced phytopreparation novoimanin and herbal formulations Hypericum.

St. John's wort – medical applications

Galenic formulations herb St. John's wort is widely used in diseases of the oropharynx, gastrointestinal tract, liver and kidneys. Infusion of St. John's wort are mouthwashes, treatment and prevention of gingivitis and stomatitis. Infusions in the form of compresses used for bleeding and infected wounds. To rinse use as tincture of Hypericum, sold in pharmacies. Pre-30-40 drops of tincture dissolved in 1/2 cup water. Recommend rinse your mouth with tincture to eliminate bad smell, and lubricate the gums for strengthening them.

St. John's wort has photosensitizing properties, t. it is. sensitizing to humans and animals to sunlight (This is attributed to the presence of St. John's wort pigment hypericin). The thickened extract of St. John's Wort in some cases, used for the treatment of vitiligo in order to eliminate depigmented (white) spots on the skin.

St. John's wort preparations used in biliary dyskinesia, gepatitah, stagnation of bile in the gall bladder, cholecystitis, with initial symptoms of gallstones, gastritis with secretory insufficiency, meteorism, as well as reducing the filtration capacity of the kidney, functional insufficiency glomerular delayed fluid and electrolytes in the body. As an aid St. John's wort preparations prescribed for urolithiasis.

In some cases, St. John's wort preparations prescribed for violations of peripheral blood with signs of stagnation, when microcirculatory disorders.

Novoimanin used externally in the form 1 % solution for 95 % alcohol when infected wounds, panaritsiyah, paronixijax flegmonax, abscesses, carbuncle, boils, gidradenitah, trophic ulcers and burns. The solution has novoimanina, bakteriostaticheskoe action of bacteria grampolozhitelynыe, inhibits their growth in the wound, It helps cleanse the wound of necrotic tissue and pus, It accelerates the process of healing, increases the regenerative properties of tissues. It noted a significant reduction in terms of recovery of patients, treated novoimaninom.

In addition to external application, several researchers apply novoimanin by electrophoresis and aerosol inhalation. Electrophoresis is prescribed for abdominal postoperative infiltrates, lymphadenitis, phlegmonous adenitis, acute hematogenous osteomyelitis, and exacerbation of chronic osteomyelitis of the long bones, various purulent lesions of the pleura and the lungs, purulent inflammation of the soft tissues, surgical wounds, at destructive appendicitis and other surgical interventions to prevent complications.

Inhalation aerosols used 0,1 % solution novoimanina. Inhalation is used for therapeutic and prophylactic treatment of bronchitis, pneumothorax, lung abscess, purulent pleurisy, pneumoempyema, anginakh, exacerbation of chronic tonsillitis, with acute respiratory diseases, etc.. d.

Novoimanin very effective and as an external agent (dressing, Aerosols, electrophoresis) when abstsedirukntsih pneumonia, in diseases of the ear, nose and throat, including chronic tonsillitis in children.

Application 0,1 % novoimanina solution is contraindicated in rapidly developing granulations due to drying and wrinkling their, which may be accompanied by small bleedings.

St. John's wort – Dosage Forms, Dosing and Administration

A decoction of herbs St. John's wort: 10g (1,5tablespoons) raw material is placed in an enamel bowl, Pour 200 ml (1 glass) hot boiled water, capped and heated in boiling water (in a water bath) 30 m, cooled for 10 min at room temperature, filter, the remaining raw materials squeeze.

The volume of the resulting broth bring boiled water to 200 ml. The prepared broth is stored in a cool place no more 2 d.

Is the inside of 1/3 cup 3 times a day 30 minutes before eating.

Grass stored in dry, cool place.

Herb St. John's wort. Prepare a ratio 1:5 on 40 % alcohol. Used as an astringent and anti-inflammatory agent in the dental practice. Inside appoint 40-50 drops 3-4 times a day. To rinse 30-40 drops to a glass of water.

Novoimanin (Novoimaninum) - Polyphenol complex preparation. Transparent resinous reddish-yellow mass with the smell of honey. Available in the form 1 % solution for 95 % ethanol. For outdoor use, inhalations, and is used in otorhinolaryngology 0,1 % solution formulation, which was prepared dilution 1 % alcohol solution 0,25 % solution or anestezina 10 % glucose solution, or isotonic sodium chloride solution or distilled water.

Solutions, obtained by dilution 1 % alcohol solution novoimanina, suitable for use during the day.