ZOVIRAKS

Active material: Acyclovir
When ATH: D06BB03
CCF: Antivirals for external and local application
ICD-10 codes (testimony): A60, B00
When CSF: 09.02.01
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)

Pharmaceutical form, composition and packaging

◊ Cream for external application 5% white or nearly white, uniform.

Excipients: propylene glycol, white soft paraffin, cetostearyl alcohol, Liquid paraffin, poloxamer 407, sodium lauryl, Dimethicone, glycerol monostearate, macrogol stearate, Purified water.

2 g – aluminum tuba (1) – packs cardboard.
2 g – Plastic bottles with a dosing device (1) – packs cardboard.

Pharmacological action

Antivirals for external and local application. Acyclovir active in otnoshenii Herpes simplex 1 and 2 types, вируса Varicella zoster , Epstein-Barr virus and citomegalovirusov.

Thymidine kinase infected cells through a series of sequential reactions actively converts acyclovir into a mono, di- and acyclovir triphosphate. Last interacts with the viral DNA polymerase and incorporated into DNA, which is synthesized for new viruses. Thus, formed “defective” viral DNA, which leads to suppression of new generations of virus replication.

Pharmacokinetics

When reapplying cream minimum systemic absorption.

Testimony

- Infections of the skin and mucous membranes, caused by Herpes simplex virus types 1 and 2, incl. Lip herpes.

Dosage regimen

The drug is recommended to apply 5 time / day (approximately every 4 no) a thin layer to the affected and adjacent to them, skin and mucous membranes.

Length of treatment – no less 4 days. In the absence of wound treatment can be extended to 10 days. If you save more symptoms 10 days, Talk to your doctor.

The cream is applied either with a cotton swab, or clean hands, to avoid further infection of affected areas.

Side effect

Local reactions: sometimes – transient redness, itch, peeling, burning or stinging at the application site preparation.

Allergic reactions: rarely – atopic dermatitis (often associated with the response to the excipients); in a few cases – angioedema.

Contraindications

- Hypersensitivity to acyclovir and other ingredients.

Pregnancy and lactation

Adequate and well-controlled clinical studies on the safety of drugs in pregnancy has not been. The application is shown only in those cases, when the intended benefits to the mother outweighs the potential risk to the fetus.

Cautions

To achieve maximum therapeutic effect the drug has to be applied at the first sign of the disease (burning, itch, pricking, a feeling of tension and redness).

When expressed manifestations of herpes of the lips is recommended to consult a doctor.

Cream should not be applied on the mucous membranes of the mouth and eyes, tk. possible development of local inflammation.

In the treatment of genital herpes are advised to avoid sex or use condoms, tk. the use of acyclovir does not prevent transmission of the virus through sexual contact.

Patients with immune deficiency in the treatment of any infectious diseases should follow the doctor's recommendations.

Overdose

Data on drug overdose Zovirax^® no.

Drug Interactions

The interaction of the drug Zovirax^® with other drugs is not detected.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C. Do not freeze. Shelf life in the aluminum tube – 3 year, in a plastic bottle with a metering device – 2 year.