Larkspur setchatoplodnaya, high, matted – Delphinium dictyocarpum DC.

Herbaceous perennials height 1,5 - 2 m, families lyutikovыh (Buttercup). Larkspur grows in the European part of Russia, in Siberia, in Central Asia. For medical purposes, harvest grass plants.

The chemical composition of larkspur

At the grass roots and larkspur setchatoplodnoy and other alkaloids contained (2-4 % by weight of dry material), mainly delsemin, melliktin, elatin and kondelfin, and other plant compounds (organic acid, mineral salts).

Pharmacological properties larkspur

Contained in the plant alkaloids delsemin, Gelatin, melliktin and kondelfin are kurarepodobnymi means, deystvuyuschymy on the competitive type. They inhibit the transmission of excitation from motor nerves to muscles, Does n-holinoreaktivnye autonomic ganglia, resulting in significantly reduced blood pressure. On the mechanism of action of neuromuscular conductivity alkaloids setchatoplodnoy larkspur and other variations are close to the d-tubocurarine. Also ganglioblokiruyuschimi action, Delphinium alkaloids have some depressing properties in the higher parts of the central nervous system; in particular, established oppression subcortical centers of the brain under the influence of alkaloids.

Alkaloid elatin unlike other alkaloids curariform larkspur is effective not only when administered parenterally, but also in domestic use.

Application of larkspur in medicine

Alkaloids plant served as the basis for the development of the three treatment drugs - elatina, kondelfina and melliktina, which are medicinal properties (kurarepodobnymi action) were so close, that is currently in the range of medicines left only melliktin.

Preparations, isolated from the plant, effective in various neurological diseases, accompanied by pathologically increased muscle tone (with the defeat of the pyramidal system), and other disorders of motor function organism (hyperkinesis, catalepsy), associated with the pathology of the central nervous system (parkinsonizm, spastic paralysis traumatic, multiple sclerosis), and in cases of postoperative, traumatic and infectious lesions of the spinal cord.

Treatment with drugs, larkspur, in particular melliktinom, usually combined with exposure to pathogenic agents, physiotherapy, reflexology treatments, performing therapeutic exercises, etc..

Contraindications melliktina serve as myasthenia gravis and other diseases, accompanied by a decrease in muscle tone. Do not prescribe the drug for severe violations of the liver and kidneys, as well as cardiac decompensation. In case of hypersensitivity to the drug or overdose melliktina necessary to eliminate the respiratory depression and a sharp kurarepodobnoe action by intravenous administration of anticholinesterases (proserin, talents, etc. n.), inhalation of oxygen and artificial respiration.

Formulations larkspur, Dosing and Administration

Melliktin - A white crystalline powder bitter taste, it is soluble in water. Apply for the reduction of muscle tone in the pyramidal insufficiency of vascular and inflammatory origin, postencephalitic parkinsonism and Parkinson's disease, Little's Disease, arahnoentsefalite and spinal arachnoiditis and other diseases of the pyramidal and extrapyramidal nature, accompanied by an increase in muscle tone and motor function disorders.

Assign inside of 0,02 g, beginning with 1 times and adjusted to 5 once a day. The course of treatment 3 Sun. to 2 Months. After a 3-4-month break, repeat the treatment.

Stored in dry, protected from light.