Xanthinol nicotinate
When ATH:
C04AD02
Characteristic.
The white crystalline powder. Easily soluble in water, little - in alcohol.
Pharmacological action.
Vasodilator, antiagregatine, antiateroskleroticheskoe.
Application.
Infringement cerebral circulation, atherosclerosis of the brain,obliterating atherosclerosis of the lower extremities, Raynaud's disease, Buerger's disease, occlusive disease, acute arterial thrombosis, diabetic angiopathy, retinopathy, acute thrombophlebitis (superficial and deep veins), post-thrombotic syndrome, venous leg ulcers, bedsores, migraine, Meniere's syndrome, dermatosis (because of the violation of the trophic vascular genesis), coronary atherosclerosis, hypercholesterolemia, hypertriglyceridemia, natal and post-natal asphyxia.
Contraindications.
Hypersensitivity, severe congestive heart failure, acute bleeding, acute myocardial infarction, gastric ulcer and duodenal ulcer in the acute stage.
Restrictions apply.
Hypotension, pregnancy (especially in the I trimester).
Side effects.
Hypotension, transient feeling of warmth, redness of the skin, weakness, dizziness, nausea, diarrhea, anorexia, gastralgia. When long-term high doses — reduced tolerance to glukoze, increase in liver transaminases and alkaline phosphatase, hyperuricemia.
Cooperation.
Strengthens (mutually) the effect of antihypertensive drugs (beta-blockers, ergot alkaloids, alpha-blockers, simpatolitikov, ganglioblokatorov).
Dosing and Administration.
Inside (after meal), begin with 150 mg 3 once a day, If necessary, increase the dose to 300-600 mg 3 once a day. / M impose on 2-6 ml 15% solution for 2-3 weeks. In / jet - By 2 ml 15% solution 1-2 times a day for 5-10 days (wherein the patient must be in a horizontal position). B / drip administered at a rate of 40-50 drops / min, breeding 10 ml 15% solution in a 200-500 ml 5% glucose solution or 200 ml of isotonic sodium chloride solution.
Precautions.
Caution should be exercised with concomitant administration of antihypertensive drugs and strofantinom.
