Volostockletocny leukemia-treatment. Symptoms and prevention of the disease volostockletocny leukaemia

Волосатоклеточный лейкоз – это один из вариантов течения хронического лимфолейкоза, which, However, at the moment it is considered self Nosology (then there are individual disease). Feature of this disease is an unusual form, which take lymphocytes. According to the statistics, volostockletocny leukaemia mainly strikes the body of the elderly (on average over 50 years), as well as than men, than women.

Volostockletocny leukaemia-causes

To date, the cause of volosatokletochnogo leukemia is not known. Development mechanism lies in the specific violations in the process of formation of blood cells (gemopojeze). Normal blood stem cells formed new blood, platelets and leukocytes. However, sometimes it happens, that during this process produces too many cells-lymphocytes, that have an abnormal structure and not being able to perform its functions. These cells are called leukemia. Leukemia cells can accumulate in the blood and bone marrow, gradually displacing healthy red blood cells.

Although it is not known, for what reason this cell, the anomaly, but it is considered to be, that certain factors can increase the likelihood of chronic leukemia, including volosatokletochnogo. It:

• exposure to ionizing radiation;
• acceptance of large quantities of carcinogens;
• genetic predisposition.

The symptoms of hairy cell leukemia

Clinical manifestations of the disease are not immediately and evolve gradually. In the early stages of the disease may complete absence of symptoms. However, it soon appears weakness and slow, but permanent weight loss. There is anemia, reduced immunity and, Consequently, frequent infections. Soon you receive loss of appetite and feeling rapid saturation of the food. It is also possible to lymph nodes in the armpits, neck and groin. A characteristic feature of volosatokletochnogo leukemia is moderate splenomegaly (a gradual increase in the size of the spleen). In this regard, the pain may occur under the ribs and a feeling of heaviness in the left abdomen.

Also symptomatic of volosatokletochnogo leukemia may be frequent bleeding, wheezing and shortness.

Volostockletocny leukaemia-Diagnostics

To confirm the diagnosis of leukemia volosatokletochnogo conducted a thorough medical history and blood test. When analyzing the blood, usually, presence is detected specific to the disease "hairy" cells, as well as thrombocytopenia and neutropenia. Also in some cases bone marrow microscopic examination. For this is done trepanobiopsy of the ilium. Sometimes as an additional method of diagnosis applied computed tomography.

Differential diagnosis of leukemia volosatokletochnogo is carried out with such diseases, as chronic lymphocytic leukemia, lymphoma, sublejkemicheskij myelosis, malignant Histiocytosis and monocitarnyj leukemia.

Volostockletocny leukaemia-types of the disease

There are four clinical group volosatokletochnogo leukemia:

• Ia/b – подозрение на наличие волосатоклеточного лейкоза/ предопухолевое заболевание;
• II – нелеченный волосатоклеточный лейкоз;
• III – волосатоклеточный лейкоз в стадии ремиссии;
• IV – волосатоклеточный лейкоз, not amenable to treatment (refractory).

Volostockletocny leukaemia patient actions

When it detects the symptoms described above, we recommend that you consult your doctor immediately to diagnose. It should be remembered, that the treatment of leukemia, begun in the early stages, gives significantly better prognosis.

Treatment of hairy cell leukemia

Volosatokletochnogo treatment of leukemia by chemotherapy. In case of a significant splenomegaly demonstrates the surgical removal of the spleen. In some cases, as monotherapy or as an adjunct to chemotherapy may be assigned the use of monoclonal antibodies. It is rarely applied preparations of interferon.

Volostockletocny leukaemia-Complications

Volosatokletochnogo complications of leukemia associated with the reduction of the number of normal blood cells, resulting in a sharp decline in immunity. As a consequence, there is a high likelihood of infectious diseases, which are recurrent in nature. The decline in the number of healthy platelets, in turn, leads to disruption of blood clotting and bleeding. Besides, considered, that one of the possible complications of leukemia volosatokletochnogo is a secondary cancer (hodgkinskaya lymphoma and Lymphoma).

Prevention of hairy cell leukemia

Specific volosatokletochnogo prevention of leukemia does not exist, However, it is recommended to avoid unfavorable factors, increase the likelihood of developing cancer, namely, ionizing radiation and reception of carcinogens.