Effect of drugs on the physiological system and the regulation of body functions
In medical practice for the treatment of a disease can be used drugs with different mechanisms of action. For Example, for optimum use of antihypertensive effect klonidin (inhibits the activity of neurons in the vasomotor center, It reduces the efferent impulses of the sympathetic nervous system to the heart and blood vessels), gidralazin (myotropic has antispasmodic action) and diuretics (increase the sensitivity of the blood vessels to the action of clonidine and apressina). For the treatment of cardiovascular disease using cardiac glycosides in combination with diuretics. With the increased secretion of gastric juice is used in conjunction with antacids holinoblokatorami or M-H2-gistaminoʙlokatorami.
In this type of interaction of drugs increases the likelihood of adverse effects or enhance. Diuretic, causing hypokalemia, combined with muscle relaxants peripherally acting or cardiac glycosides can cause cardiac arrhythmias.
As an example of the interaction of drugs, affecting the regulation of functions in the body, It may be a combination of papaverine hydrochloride (dilates blood vessels, lowers blood pressure, causing compensatory tachycardia) and other antispasmodics myotropic action with β-blockers (It prevents the development of tachycardia and enhances the hypotensive effect).
