Vinpocetine

When ATH:
N06BX18

Characteristic.

The white crystalline powder, practically insoluble in water, soluble in alcohol.

Pharmacological action.
Vasodilator, antiagregatine, improving cerebral circulation, antihypoxia.

Application.

Cerebrovascular accident (incl. stroke, vertebral-basilar insufficiency, injury, atherosclerotic changes in cerebral vessels, sosudistaya dementia, idiopathic and post-traumatic encephalopathy), intermittent failure and cerebral vasospasm; partial occlusion of arteries, headache, dizziness (incl. labyrinthine origin), memory impairment, movement disorders, incl. apraxia, afazija, arterioloskleroticheskie angiospastic and changes of the retina and choroid, arterial and venous thrombosis eyes, macular degenerative changes, secondary glaucoma due to the obstruction of vessels; age, Vascular or toxic (medication) hearing loss, Meniere's disease, kohleovestibulârnyj neuritis, noise in ears; vazovegetativnye manifestations of climacteric syndrome (in combination with hormone therapy).

Contraindications.

Hypersensitivity, severe forms of ISCHEMIC HEART DISEASE and arrhythmias, the first days after cerebral hemorrhagic stroke, increased intracranial pressure; pregnancy, lactation.

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: dizziness, headache, insomnia, drowsiness, weakness.

Cardio-vascular system and blood (hematopoiesis, hemostasis): slowing vnutrijeludockova conductivity; ST segment depression and elongation QT interval, gipotenziya, tachycardia, arrythmia, erythema, thrombophlebitis at the injection site.

From the digestive tract: dry mouth, nausea, heartburn.

For the skin: Sweating.

Other: allergic reactions.

Cooperation.

Increases the risk of bleeding complications in geparinoterapii. Do the gipotenziveh funds.

Overdose.

Treatment: gastric lavage, appointment of activated carbon, simptomaticheskaya therapy.

Dosing and Administration.

Inside, after meal, on the 5-10 mg 3 once a day. Supporting dose is on 5 mg 3 once a day. The course of treatment for 2 Months.

B / drop, slowly (maximum speed infusion — 80 drops / min), on 10-20 mg in 500-1000 ml izotoniceski solution of sodium chloride. When you need within 3-4 days dose increase to a maximum- 1 mg / kg / day. The course of treatment is 10-14 days. Then, go to the reception of the drug inside (by 10 mg 3 once a day) with a gradual decrease in dose before canceling.

Precautions.

Not recommended to appoint labil′nom HELL and lower vascular tone.

Be wary appoint patients, receiving gipotenzivee drugs or medication, prolonging the QT interval, as well as patients with poor tolerance of Vinca alkaloids are small (Vinca minor) and suffering from liver failure.

Not allowed s/c, the/m and/in a Jet.

Should not be used during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cautions.

For parenteral administration, diabetics need to control blood glucose (solution contains sorbitol). In the presence of long QT syndrome, or concomitant use of drugs, provoking QT prolongation, requires monitoring of ECG.

In hemorrhagic stroke parenteral use of the drug is allowed only after the disappearance of acute effects (5-7 days).

There is a sufficient number of observations on the use of the drug in pediatric practice.