Valsartan

When ATH:
C09CA03

Characteristic.

White or almost white powder. Soluble in ethanol and methanol, slightly soluble in water. Molecular weight 435,5.

Pharmacological action.
Antigipertenzivnoe.

Application.

Arterial hypertension; Chronic heart nedostatochnoct (II-IV functional class NYHA classification) in the complex therapy; improved survival of patients with acute myocardial infarction, complicated by left ventricular failure and / or left ventricular systolic dysfunction, in the presence of a stable hemodynamic.

Contraindications.

Hypersensitivity, pregnancy, lactation.

Restrictions apply.

Age to 18 years (efficacy and safety have not been proven).

Pregnancy and breast-feeding.

Contraindicated in pregnancy.

Category actions result in FDA - D. (There is evidence of the risk of adverse effects of drugs on the human fetus, obtained in research or practice, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk, if the drug is needed in life-threatening situations or severe disease, when safer agents should not be used or are ineffective.)

At the time of treatment should stop breastfeeding (unknown, whether valsartan is excreted into breast milk).

Side effects.

From the nervous system and sensory organs: seldom-weakness, headache, dizziness.

From the digestive tract: seldom-diarrhoea, nausea, abdominal pain, increase in liver transaminases.

Cardio-vascular system and blood (hematopoiesis, hemostasis): rarely, neutropenia (1,9%), anemia, decrease in hematocrit.

Other: seldom-cough, hyperkalemia, viral infections.

Cooperation.

Strengthens (mutually) hypotensive effect of diuretics. Potassium-sparing diuretics, and preparations, containing potassium, increase the risk of hyperkalemia.

Overdose.

Symptoms: gipotenziya, tachycardia or bradycardia.

Treatment: simptomaticheskaya therapy; dialysis nyeeffyektivyen.

Dosing and Administration.

Inside, the recommended dose in hypertension 80 mg 1 once a day; When lack of effectiveness may increase doses up to 160 mg supplementation or other antigipertenzivnogo drug (such as a diuretic). The maximum daily dose 320 mg.

Precautions.

Caution must be exercised in the appointment of patients with deficiency of sodium and / or a marked reduction in BCC (because of the increased risk of excessive hypotension), with bilateral renal artery stenosis or renal artery stenosis sole kidney (requires monitoring of serum creatinine and serum urea nitrogen), with severe renal impairment (creatinine clearance less than 10 ml / min), severe hepatic impairment, biliarnym cirrhosis, obstruction of the biliary tract, with concomitant use of potassium-sparing diuretics, potassium-containing medications or potassium supplements. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.