Scientists have discovered that ibuprofen's ability to prolong life
Along with the increase in life expectancy ibuprofen significantly reduces the average size of the cells at its birth.
US and Russian scientists have discovered that the drug ibuprofen's ability to prolong life. This was reported by the authors in their article in the journal PLoS Genetics.
Ibuprofen belongs to a group of common non-steroidal anti-inflammatory drugs. The main active ingredient of this tool is based on propionic acid.
The product was created in the 1960s in the UK, where he first became available by prescription. Already in the 1980s, the prevalence of vehicle has received worldwide. The product has analgesic and antipyretic activity and is included in the list of essential medicines WHO.
In their study, the researchers showed, Ibuprofen increases the lifespan of baker's yeast (Saccharomyces cerevisiae), free-living nematodes (Caenorhabditis elegans) and chernobryushechnyh Drosophila (Drosophila melanogaster).
Organisms after taking ibuprofen lived on 15% longer. Besides, It was healthier compared with organisms, which do not have access to the drug.
According to experts, based on the person, this may mean an increase in the lifetime for a period of ten years.
Studies in yeast showed, Ibuprofen is destabilizing and inhibits permease Tat2p (slows) uptake of tryptophan and other aromatic acids. Loss Tat2p increases replicative life span (to, how many times a cell can divide).
Along with the increase in life expectancy ibuprofen significantly reduces the average size of the cells at its birth. This leads to delays in G1-phase of the cell cycle. At this stage of the cell cycle proteins and mRNA synthesized, required for DNA synthesis, and it becomes clear, will share a cell to a state of rest (G0-phase).
“Buck Institute is interested in the study of the causes, why people get sick during aging. We believe, what, Realizing this, we will be able to step in and find ways to save human health and slow down aging. It is our ultimate goal”, – said Brian Kennedy, Head of the institute , in conducting research.
About a year ago, scientists discovered and anti-cancer properties of the drug. In the new study,, as the authors note, they found a rejuvenating effect of ibuprofen, regardless of the anti-inflammatory role.
According to geneticists, Given the widespread and studied drugs, It is an interesting question to further study the effects of drugs, especially in the context of identifying characteristics of the cell cycle, associated with longevity.
