Tuchnokletochnыy leukemia

Tissue basophils (mast cells) They found almost everywhere. Proved, that they have a hematogenous origin. Grain their cytoplasm largely similar to grain basophils, It contains sulfated acidic glycosaminoglycans (mukopolisaxaridы).

Tumors of the tissue basophils - mastocytosis

Tumors of the tissue basophils - mastocytosis - rare. Among the most common xanthelasmoidea (urticaria pigmentosa). It is characterized by small papules, urticaria, bullous eruptions and diffuse pinkish. The process can progress and capture the internal organs: Bone marrow, liver, selezenku, The lymph nodes. Bone lesions manifested diffuse osteolysis or osteosclerosis. Radiological findings in the first case, a bone resorption up to the formation of large destructive zones, Second - the picture recalls osteosclerosis.

Bone marrow and organ optional hematopoiesis suggests mast cell leukemia, which should be attributed to the chronic form, as its substrate is predominantly mature, although somewhat atypical, tkanevыmi ʙazofilami.

Maetotsitozy occur in children (even in newborns), in adults, progressing very slowly. Children sometimes marked regression of the process.

Diagnosis of acute mast cell leukemia

Acute leukemia tuchnokletochnыy, as a very rare disease, Until recently, attributed, apparently, a promyelocytic leukemia, chronic form. However, in contrast to cells of acute promyelocytic leukemia cells are acute mast cell leukemia give a negative reaction to peroxidase at a positive reaction to hloratsetatesterazu.