TSITOFLAVIN

Active material: combined preparation
When ATH: N06BX
CCF: Preparation, improves the metabolism of the brain
ICD-10 codes (testimony): F07, F48.0, G45, G92, G93.4, I61, I63, I67.2, I67.4, I69
At KFU: 02.14
Manufacturer: POLYSAN NTFF Ltd. (Russia)

Pharmaceutical form, composition and packaging

Pills, enteric coated of red color, round, lenticular.

Excipients: polyvinyl MIDDLE (povidone), calcium stearate, a copolymer of methacrylic acid and ethyl acrylate, 1,2-propylene glycol, Acid Red 2C, About tropeolin.

10 PC. – packings Valium planimetric (5) – packs cardboard.
10 PC. – packings Valium planimetric (10) – packs cardboard.
50 PC. – plastic jars (1) – packs cardboard.
100 PC. – plastic jars (1) – packs cardboard.

The solution for the on / in the clear, yellow color.

Excipients: meglumin (N-methylglucamine), Sodium hydroxide, water d / and.

5 ml – ampoule (5) – packings Valium planimetric (1) – packs cardboard.
5 ml – ampoule (5) – packings Valium planimetric (2) – packs cardboard.

The solution for the on / in the clear, yellow color.

Excipients: meglumin (N-methylglucamine), Sodium hydroxide, water d / and.

5 ml – bottles (10) – packs cardboard.

The solution for the on / in the clear, yellow color.

Excipients: meglumin (N-methylglucamine), Sodium hydroxide, water d / and.

10 ml – ampoule (5) – packings Valium planimetric (1) – packs cardboard.
10 ml – ampoule (5) – packings Valium planimetric (2) – packs cardboard.

Pharmacological action

Metabolic drug. The pharmacological effects are due to the combined action of members of the drug Citoflavin^® Components. It stimulates the cellular respiration and energy production, improves the process of tissue oxygen utilization, restores the activity of enzymes, providing an antioxidant effect.

The drug activates the intracellular protein synthesis, promotes glucose utilization, fatty acids and resynthesis of GABA in the neurons through the shunt Roberts.

It has a positive effect on the brain bioelectrical activity.

Tsitoflavin^® It improves the brain and coronary blood flow, activates metabolic processes in the CNS, reduces reflex disorders, It contributes to the restoration of impaired sensitivity and intellectual-mental functions of the brain.

Positive effect on the parameters of neurological status: reduces the severity of asthenic, cephalgic, vestibular-mozzhechkovoho, cochleovestibular syndrome, and also eliminates frustration in the emotional and volitional (reduces anxiety, depression). It improves cognitive mnemonic function and quality of life.

The on / in the introduction helps to restore impaired consciousness. It has a rapid awakening effect in postanesthetic depression of consciousness. When using Cytoflavin^® first 12 h of the onset of stroke observed beneficial for ischemic and necrotic processes in the affected area (reduction focus), restoration of neurological status and reduction of disability in the long term.

Pharmacokinetics

When i / v infusion at a rate of approximately 2 ml / min (based on the undiluted Citoflavin^®) succinic acid and inosine are utilized almost instantaneously and blood plasma are not determined.

Inozin It is metabolized in the liver with the formation and subsequent oxidation of hypoxanthine to uric acid. The small amount excreted by the kidneys.

Nicotinamide rapidly distributed in all tissues, It crosses the placental barrier, excreted in breast milk. It is metabolized in the liver with the formation of nicotinamide-N-methylnicotinamide, excreted by the kidneys. T_1/2 from plasma is about 1.3 no, V_ss - About 60 l, total clearance – about 0.6 l / min.

Riboflavin unevenly distributed: most – myocardium, liver, kidneys. T_1/2 from plasma is about 2 no, V_ss – about 40 l, total clearance – about 0.3 l / min. It penetrates through the placental barrier, excreted in breast milk. Plasma protein binding – 60%. Report the news, partially Vide metabolite; when used in high doses – mainly unchanged.

Testimony

Pills

In the combined therapy in adults:

- Chronic cerebral ischemia 1-2 stage (cerebral arteriosclerosis, hypertensive encephalopathy, the effects of stroke);

- Asthenic syndrome (malaise and fatigue).

The solution for the on / in the

In the combined therapy in adults:

- Acute ischemic stroke;

- Circulatory (Cardiovascular) encephalopathy 1-2 stage and the consequences of cerebral circulatory disorders (chronic cerebral ischemia);

- Toxic and hypoxic encephalopathy with acute and chronic poisoning, endotoxemia, oppression of consciousness after anesthesia.

Dosage regimen

Pills

Inside take on 2 tab. 2 times / day for 30 minutes before eating, not liquid at intervals 8-10 no (wash down 100 ml of water). Duration of the course – 25 days (100 tab.). Evening reception of the drug is recommended no later than 18 no.

Appointment Repeated courses with an increase in cerebrovascular insufficiency, but not earlier than 25-30 days after the end of the previous course.

The solution for the on / in the

Tsitoflavin^® introduced only in / drip in a dilution in the 100-200 ml 5-10% glucose solution, 0.9% sodium chloride solution.

At acute stroke the drug is administered as early as possible after the onset of the disease in the volume 10 ml for administration at intervals 8-12 h for 10 days. In severe form of the disease a single dose increased to 20 ml.

At vascular encephalopathy and cerebrovascular pocledstviyah Tsitoflavin^® administered at a dose of 10 ml for 1 introduction 1 times / day for 10 days.

At toxic and hypoxic encephalopathy preparation is administered in a dose of 10 ml for 1 introduction 2 times / day after 8-12 h for 5 days.
At coma preparation is administered in a volume 20 ml dilution for introduction into the 200 ml glucose solution.
At oppression of consciousness after anesthesia once the drug is administered in the same doses.

Side effect

With the rapid on / in a drip: possible flushing of the skin of varying severity, feeling the heat, bitterness and a dry mouth, sore throat. These adverse reactions do not require discontinuation of the drug.

Chronic administration of high doses: possible transient hypoglycemia, hyperuricemia, worsening of gout.

From the digestive system: at / in a rare – short-term pain and discomfort in the epigastric region, nausea.

The respiratory system: at / in the drip rarely – intermittent pain and discomfort in the chest, difficulty breathing, tingling sensation in the nose.

CNS: When ingestion possible transient headache; at / in the drip rarely – headache, dizziness.

Allergic reactions: possible itching.

Other: at / in the drip rarely – dysosmia, blanching of the skin of varying severity.

Contraindications

- Lactation (for / in the);

- Hypersensitivity to the drug.

Patients, on mechanical ventilation, not recommended Citoflavin^® with a decrease in the partial pressure of oxygen in arterial blood below 60 mmHg.

FROM caution the solution should be used for I / O administration for nephrolithiasis, podagre, hyperuricemia.

FROM caution Tablets should be administered Citoflavin^® in diseases of the digestive tract (erosive gastroduodenitis, peptic ulcer).

Pregnancy and lactation

If necessary, you can use the drug orally during pregnancy and lactation (breast-feeding) in the absence of allergic reactions to the drug components.

In / in the introduction of the drug during pregnancy allowed, lactation (breast-feeding) – contraindicated.

Cautions

When receiving Cytoflavin^® inside may require adjustment of doses of antihypertensive drugs in patients with hypertension.

In critical states in / at the introduction of the drug is possible after normalization of central hemodynamics.

The treatment should be to control the level of glucose in blood plasma.

Against the background of administration possible staining of urine a pale yellow color.

Effects on ability to drive vehicles and management mechanisms

When administered drug does not affect the ability to concentrate.

Overdose

Symptoms of overdose Citoflavin^® not found.

Drug Interactions

Succinic acid, inosine and nicotinamide (active ingredients of the drug Citoflavin^®) compatible with other medicaments.

Tsitoflavin^® compatible with the means, stimulating hematopoiesis, antioxidants and anabolic steroids.

In an application Cytoflavin^® should be considered, that included in its composition riboflavin reduces the activity of doxycycline, tetracycline, oxytetracycline, erythromycin and lincomycin; nesovmestim with streptomicinom.

The combined application with cytoflavin^® chlorpromazine, imizin, amitriptyline due to blockade flavinokinazy violate inclusion in flavinadeninmononukleotid riboflavin and flavin adenine dinucleotide and increase its excretion in the urine.

With simultaneous use of thyroid hormones accelerate the metabolism of riboflavin.

In a joint application Citoflavin^® reduces and prevents the development of side effects of chloramphenicol (hematopoietic disorders, optic neuritis).

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children, dry, protected from light. Tablets should be stored at a temperature no higher than 25 ° C, solution in / in – at a temperature of from 18 ° to 20 ° C. Shelf life – 2 year.

Storage solution for the on / in the light on unacceptable! The formation of sludge is prohibited to use the drug.