Trypsin

When ATH:
D03BA01

Characteristic.

Endogenous proteolytic enzyme class of hydrolases, catalyzes the cleavage, incl. proteins, leptons, low molecular weight peptides Relations, in education which participate carboxyl group of L-arginine and L-lysine. Trypsin is a protein with a relative molecular mass 21000, It is produced and secreted by the pancreas of mammals as an inactive trypsinogen, which is then transformed into trypsin by the enzyme enteropeptidase duodenum.

Trypsin is obtained from the pancreas of cattle followed by lyophilization. In medical practice using crystalline trypsin (It allowed for local, and for parenteral use) and trypsin amorfnыy (Only topical).

Trypsin is crystalline powder white or white with a slightly yellowish brown color, without smell, or porous mass (After lyophilization). Easily soluble in water, isotonic sodium chloride solution; solutions are easily destroyed in neutral and alkaline media.

Developed special dosage forms crystalline trypsin for the treatment of purulent wounds — trypsin immobilized on a special polymer basics (cloth): of dialydegidtsellyuloze or aktivirovannom trikotazhnom poliamidnom polotne; issued size cuts of web 10 × 7,5 cm to 30 cm × 20.

Pharmacological action.
Proteolytic, anti-inflammatory, catalytic regeneration.

Application.

Respiratory system diseases (incl. tracheitis, bronchitis, bronchiectasis, pneumonia, postoperative pulmonary atelectasis, empyema, pleural effusion), tromboflebit, parodontoz (inflammatory and degenerative forms), osteomyelitis, genyantritis, otitis, Irit, iridocyclitis, bleeding in the anterior chamber of the eye, periorbital swelling after surgery or injury, burns, bedsores; sores (locally).

Contraindications.

For injecting - Cardiac decompensation, emphysema with respiratory failure, decompensated forms of pulmonary tuberculosis, roasted dystrophy, cirrhosis of the liver, infectious hepatitis, pancreatitis, gyemorragichyeskii diatyez. You can not enter into oral bleeding, I /, applied to the surface of ulcerated tumors.

Side effects.

Allergic reactions, fever, tachycardia; When the/m introduction-pain, redness at the injection site; in inhalation introduction is irritation of the mucous membranes of the upper respiratory tract, hoarseness.

Dosing and Administration.

/ M: adults-to-0.01 0.005 g 1-2 times a day; children - 0,0025 g 1 once a day; extemporaneously 0,005 g of crystalline trypsin dissolved in 1-2 ml of sterile 0,9% sodium chloride solution or 0.5-2% solution of procaine. The course of treatment is 6-15 injection. Applied also Electrophoresis with trypsin: per procedure 10 mg of trypsin (dissolved in 15-20 ml of distilled water) administered with the negative pole.

Inhalation: of 0.005-0.01 g in 2-3 ml 0,9% solution of sodium chloride is injected in the form of an aerosol or via inhaler through bronchoscope. After inhalation should rinse your mouth with warm water and rinse your nose.

In the form of eye drops: solution (0,2-0,25%) prepared immediately before use.

Intrapleural: 1 once a day, 10-20 mg of previously dissolved in 20-50 ml 0,9% sodium chloride solution.

Locally: in the form of powders of amorphous or trypsin solution, on dry or necrotic wounds apply compresses (solution was prepared immediately before use: 50 mg trypsin dissolved in 5 ml of sterile water or 0,9% sodium chloride solution, in the treatment of purulent wounds — in 5 ml of phosphate buffer solution).

Cloth, propytannoe trypsin, applied to the wound (after treatment), fixed bandage on the wound and allowed to 24 no. Before applying the fabric is moistened with saline, distilled or boiled water or antiseptic solution (eg Furatsilin). Maintain wet, soaking through the bandage. Suhaia napkin inactive. Complete cleanse wounds of necrotic tissue and the pus is 24-72 h. If you want to re-apply.