TRIMETAZID

Active material: Trimetazidine
When ATH: C01EB15
CCF: Preparation, improving myocardial metabolism, and neurosensory organs in ischemia
ICD-10 codes (testimony): H35.0, H81, H93.0, i20, R42
When CSF: 01.12.09
Manufacturer: Pharmaceutical Works Polfa in Pabianice Joint-Stock Company (Poland)

Pharmaceutical form, composition and packaging

Pills, coated of red color, round, lenticular; at the turn of two visible layer.

Excipients: microcrystalline cellulose, croscarmellose, povidone, magnesium stearate.

The composition of the shell: metilgidroksipropilzelluloza E5, metilgidroksipropilzelluloza E15, hydroksypropyltsellyuloza, polyethylene glycol, Nail Polish cochineal Red, cochineal Red.

20 PC. – blisters (3) – packs cardboard.
30 PC. – blisters (2) – packs cardboard.
60 PC. – vials of dark glass (1) – packs cardboard.

Pharmacological action

Antianginal drug, improves metabolism of myocardium. It has antihypoxia, hypotensive and koronrodilatirtee action.

Directly improves the metabolism of cardiomyocytes and neuronal brain. Cytoprotective effect is due to an increase in the energy potential, activated oxidative decarboxylation and rationalization of oxygen consumption by increasing aerobic Glycolysis and inhibition of oxidation of fatty acids. Supports normal airway diseases, prevents intracytoplasmic ATP depletion and fosfokreatinina. In azidoza normalizes ion channels membranes, prevents accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular concentration of potassium ions. Reduces intracellular acidosis and phosphate content, due to myocardial ischemia and reperfusion. It prevents the damaging effect of free radicals, It preserves the integrity of cellular membranes, It prevents activation of neutrophils in the ischemic area, It reduces the yield of CK cells and severity of ischemic myocardial damage.

When angina reduces the frequency of seizures. Through 2 weeks of treatment increased exercise tolerance, reduced blood pressure drops. Amid the drug improves hearing and vestibular sampling results, reduces dizziness and tinnitus. When vascular pathology eye improves the functional condition of the retina.

Pharmacokinetics

Absorption

Once inside quickly and almost completely absorbed from the digestive tract. Bioavailability is 90%. After a single oral dose 20 mg C_max achieved through 2 and h is about 55 ng / ml.

Distribution

Easily penetrates through the blood-tissue barriers. Plasma protein binding is 16%.

Deduction

Report the news, about 60% – in unchanged form. T_1/2 – 4.5-5 no.

Testimony

- CHD, angina (in the complex therapy);

— horioretinale vascular violations with ischemic component;

-dizziness vascular origin;

— treatment kohleo-vestibular disorders ischemic nature (noise in ears, hearing loss).

Dosage regimen

Trimetazid designate inside in a dose 60 mg / day 2-3 admission. Duration of treatment set individually.

Tablets are taken with meals.

Side effect

From the digestive system: rarely – epigastric pain, nausea, vomiting.

Allergic reactions: itching.

Other: headache, feeling palpitations.

Contraindications

- Renal failure (CC<15 ml / min);

- Expressed human liver;

- Childhood and adolescence up 18 years;

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

Pregnancy and lactation

Trimetazid is contraindicated for use in pregnancy and lactation.

Cautions

Against the background of the use of the drug in patients with ischemic heart disease significantly reduced the daily need for nitrates.

Effects on ability to drive vehicles and management mechanisms

Trimetazidne affect the ability to drive a car and perform work, requiring a high rate of psychomotor reactions.

Overdose

Currently, the cases of drug overdose Trimetazid were reported.

Drug Interactions

Patient interaction drug Trimetazid not described.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a location protected from moisture and out of reach of children at a temperature of no higher than 25° c. Shelf life – 3 year.