Tremektal
Active material: Trimetazidine
When ATH: C01EB15
CCF: Preparation, improving myocardial metabolism, and neurosensory organs in ischemia
ICD-10 codes (testimony): H35.0, H81, H93.0, i20, R42
When CSF: 01.12.09
Manufacturer: JSC Vertex (Russia)
Pharmaceutical form, composition and packaging
Capsules hard gelatin, №3, white / orange; contents of capsules – powder white or nearly white.
| 1 caps. | |
| trimetazidina digidroxlorid | 20 mg |
Excipients: lactose, corn starch, povidone (polyvinylpyrrolidone), calcium stearate (octadecenoate).
Ingredients of the capsule shell: gelatin, azoruʙin (E122), “sunny yellow” (E110), Titanium dioxide (E171).
10 PC. – packings Valium planimetric (6) – packs cardboard.
20 PC. – packings Valium planimetric (3) – packs cardboard.
60 PC. – plastic jars (1) – packs cardboard.
Pharmacological action
Antihypoxia and antianginal drug. Directly affecting cardiomyocytes and neurons in the brain, optimizes their metabolism and function. Cytoprotective effect is due to an increase in the energy potential, activation of the oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, It prevents a decrease in intracellular ATP and phosphocreatine. Under conditions of acidosis normalizes the functioning of membrane ion channels, prevents accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular concentration of potassium ions. Reduces intracellular acidosis and phosphate content, caused by myocardial ischemia and reperfusion. It prevents the damaging effect of free radicals, It preserves the integrity of cellular membranes, It prevents activation of neutrophils in the ischemic area, increases the electrical potential, It reduces the yield of CK cells and severity of ischemic myocardial damage.
When angina reduces the frequency of seizures (reduced intake of nitrates), through 2 weeks of treatment increased exercise tolerance, reduced blood pressure drops.
Improves hearing and vestibular results of samples from patients, reduces dizziness and tinnitus.
When vascular pathology eyes restores the functional activity of the retina.
Pharmacokinetics
Absorption
After oral administration of trimetazidine quickly and almost completely absorbed from the gastrointestinal tract. Bioavailability – 90%. The time to reach Cmax plasma – 2 no. After receiving a single dose of trimetazidine 20 mg Cmax is about 55 ng / ml.
Distribution
The binding to plasma proteins – 16%.
Easily penetrates through the blood-tissue barriers.
Deduction
T1/2 is 4.5-5 no. Excreted from the body by the kidneys, about 60% – in unchanged form.
Testimony
- CHD: prevention of angina attacks (in the treatment of);
- Chorioretinal vascular disorders;
- Vertigo of vascular origin;
- Cochle-vestibular disorders ischemic nature (noise in ears, hearing disorder).
Dosage regimen
The drug is taken orally, while eating.
The recommended dosing regimen – 2-3 capsules (40-60 mg)/sut 2-3 admission. The course of treatment the doctor sets individually.
Side effect
Allergic reactions: itching.
From the digestive system: rarely – gastralgia, nausea, vomiting.
CNS: rarely – headache.
Cardio-vascular system: palpitations.
Contraindications
- Renal failure (CC less than 15 ml / min);
- Expressed human liver;
- Pregnancy;
- Lactation (breast-feeding);
- Up to 18 years (efficacy and safety have not been established);
- Hypersensitivity to the drug.
Pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breast-feeding).
Cautions
Against the background of treatment in patients with coronary artery disease there is a significant decrease in daily requirement of nitrates.
Effects on ability to drive vehicles and management mechanisms
The drug does not affect the ability to drive and perform work, requiring a high rate of psychomotor reactions.
Overdose
Currently, cases of drug overdose were reported.
Drug Interactions
Data on drug interactions drug Trimektal® no.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
List B. The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.
