TRAVOGEN

Active material: Isoconazole
When ATH: D01AC05
CCF: Antifungal agents for external use
ICD-10 codes (testimony): B35.0, B35.2, B35.3, B35.4, B35.6, B36.0, B37.2, B37.3, B37.4, L08.1
At KFU: 08.02.01
Manufacturer: INTENDIS GmbH {Germany}

Pharmaceutical form, composition and packaging

Cream 1% white or slightly yellowish, opaque.

	1 g
isoconazole nitrate	10 mg

Excipients: Liquid paraffin, sorbitan stearate, polysorbate 60, cetylstearyl alcohol, white petrolatum, Purified water.

20 г – тубы алюминиевые (1) – пачки картонные.
50 г – тубы алюминиевые (1) – пачки картонные.

Pharmacological action

The preparation for external use, synthetic imidazole derivative. It has antifungal activity, acts fungistatically.
It is active against

dermatophytes Trichophyton spp., Microsporum spp., Epidermophyton, mold, yeast and yeast-like fungi of the genus Candida, and Corynebacterium minutissium (pathogen erythrasma). Antibacterial activity against certain Gram-positive bacteria (streptococci and staphylococci).

Pharmacokinetics

When applied to the skin absorption is negligible.

Testimony

Fungal skin lesions, incl. secondarily infected:

- Tinea pedis;

- Ringworm smooth skin (incl. localized in the folds of the skin, interdigital spaces, vulva);

- Erythrasma.

Dosage regimen

Travogen applied thinly to the affected skin and gently rub: the procedure is performed 1 time / day.

The course of treatment is usually at least 2-3 weeks, and in cases refractory to therapy (in particular, with the defeat of the interdigital spaces) - To 4 weeks. Perhaps a more long-term treatment.

To prevent recurrence after resolution of clinical manifestations, treatment should continue for a further 2 weeks.

Side effect

Dermatological reactions: редко – раздражение кожи (burning sensation and itching, эritema).

Allergic reactions: in some cases - skin manifestations.

Rarely: allergic reactions.

Usually, Travogen well tolerated, even when applied to sensitive skin.

Contraindications

- Hypersensitivity to the drug.

Pregnancy and lactation

Clinical experience of using drugs during pregnancy, containing isoconazole, It does not indicate a risk of teratogenicity in humans.

Unlikely, that when used topically in dosage isoconazole be excreted in breast milk.

Cautions

The drug is intended for external use only.

In the absence of therapeutic effect within a specified time the patient should seek medical advice.

When symptoms, evidence of increased sensitivity or irritation, the drug should be discontinued.

Avoid contact with the eyes.

The patient must inform the doctor about the appearance of any undesirable effects during treatment Travogenom, as well as the simultaneous administration of other drugs.

Use in Pediatrics

Children under 2 years the drug is prescribed only under strict indications and under the supervision of a physician.

Overdose

So far, reports of drug overdose has not. Due to the low toxicity isoconazole no reason to expect the risk of acute intoxication after a single use of high-dose or inadvertent oral administration.

Drug Interactions

Clinical trials and drug application in medical practice have not revealed incompatibilities or interactions with other drugs.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored out of reach of children, at a temperature no higher than 30 ° C. Shelf life - 5 years.