Tranexamic acid: instructions for using the medicine, structure, Contraindications

When ATH:
B02AA02

Tranexamic acid: characteristic

The white crystalline powder, water-soluble. The aqueous solution has a pH 6,5-7,5.

Tranexamic acid: pharmachologic effect

Antifibrinolytic, antiallergic, anti-inflammatory.

Tranexamic acid: application

Bleeding, due to an increase in general and local fibrinolysis (Treatment and Prevention): hemophilia, hemorrhagic complications of fibrinolytic therapy, trombotsitopenicheskaya purpura, aplasticheskaya anemia, leukemia, bleeding during surgery and in the postoperative period, uterine childbirth, pulmonary, bow, gastrointestinal, Menno- and metrorrhagia, makrogematuriâ, due to bleeding from the lower urinary system; thrush, sore throat, laringofaringit, hereditary angioedema, eczema, atopic dermatitis, hives, drug and toxic rash.

Tranexamic acid: Contraindications

Hypersensitivity, subarachnoid hemorrhage, renal failure, trombofilicescie state (deep vein thrombosis, thromboembolism, myocardial infarction), impaired color vision.

Tranexamic acid: use during pregnancy and lactation

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Tranexamic acid: side effects

Dyspepsia (anorexia, nausea, vomiting, diarrhea), dizziness, weakness, drowsiness, tachycardia, chest pain, gipotenziya (With the rapid on / in a), impaired color vision, allergic skin reactions.

Tranexamic acid: interaction

Incompatible with urokinase, noradrenaline bitartrate, dezoksiepinefrinom gidroxloridom, metarminom ʙitartratom, dipiridamolom, diazepamom. A solution of tranexamic acid reacts (you can not mix) with antibiotics (benzilpenicillin, tetracikliny), blood proteins.

Tranexamic acid: Dosing and Administration

Inside (regardless of the meal) for 250-500 mg 3-4 times a day. B /, slowly, 10-15 Ml. The maximum daily dose - 2 g. When removing teeth in patients with hemophilia: before the operation simultaneously with the beginning of replacement therapy introduced in/in the dose 10 mg / kg; After the operation is on the inside 25 mg/kg 3-4 times a day for 2-8 days or inside the dose 25 mg/kg 3-4 times a day, starting over 1 the day before the forthcoming operation. Immediately prior to / in a diluted standard infusion solutions, Dextran, aminocaproic acid solution.

Tranexamic acid: precautions

In renal insufficiency (depending on the degree of increase in serum creatinine) reduce the dose and frequency of administration. During and after treatment for a few days is necessary to observe ophthalmologist with acuity, fields and color vision, fundus examination. To use caution in combination with tissue hemostatic drugs, gemokoagulazoj (large doses), geparinom. In the treatment of renal genesis of hematuria increased risk of mechanical anuria resulting in clot formation in the urethra.

Tranexamic acid: interaction