Toxic liver damage – treatment of disease. Symptoms and prevention of diseases of Toxic liver damage

Toxic liver damage – What is this disease? Toxic liver damage is a series of diseases, due to the defeat of the hepatocytes (the main liver cells) exposure to toxic substances and factors in violation of their normal functioning.

It can be various hepatosis or toxic hepatitis. This pathology is quite common, that has to do with the myriad gepatotoksicnah substances and factors.

Toxic liver damage – The cause of the

There are many different causes of toxic to liver, among which we can highlight the following:

• industrial toxins (pesticides, insekticidы, phenols, aldehydes, phosphorus, arsenic, oil components, etc.);
• · medicines, especially when exceeding recommended dosages (antituberculous drugs, sulfanilamide antimicrobials, anticonvulsants, antipyretic, antiviral agents);
• hepatotoxic substances of plant origin (poison mushrooms, weeds, aflatoxins, produced by fungi and long-term but rice, corn or grain).

The way of their getting into the human organism can also be different: alimentary path (with water or food consumption), respiratory (the air-drop way), as well as through the skin.

Factors, contributing to the defeat liver toxins are genetic predisposition to allergic reactions to proteins and/or reduced activity of protective barrier of hepatocytes system, Age more 40 years, prior liver bacterial or viral infection, environmentally unfavourable region of residence, work in hazardous work, body mass deficits or vice versa obesity, Type 2 diabetes mellitus, breach of lipid Exchange, paratrofija.

Toxic liver damage – Symptoms

Clinical manifestations with toxic liver damage variable depending on the etiological factor, severity, flow duration of pathological process and the general condition of the organism. If chronic exposure to toxic factors, symptoms may not appear for a long time or be overlooked amid other pathology. When toxic liver damage symptoms may occur:

• yellowness of the skin and mucous membranes;
• dark yellow urine;
• · light stool;
• · skin itching;
• · increased liver, its seal;
• feeling of discomfort in the right hypochondrium, in okolopupochnoj zone;
• · nausea, recurring vomiting;
• · decreased appetite, bitter taste in the mouth;
• · bloating;
• · erythema (mainly on the palms and soles);
• · telangiectasias (Vascular "stars");
• gynecomastia in men;
• · sexual dysfunction;
• tendency to bleed (angiostaxis);
• liver odor from the mouth;
• · irritability, drowsiness, but severe cases can develop human consciousness until coma hepatic.

Toxic liver damage – Diagnostics

In the diagnosis of toxic liver disease following laboratory and instrumental research methods:

• severe conditions (leukocytosis, eozinofilija, ESR acceleration);
• physical examination (elevated levels of bilirubin, the activity of hepatic transaminases-Alat, AsAT, alkaline phosphatase, violation ratios of protein fractions, etc.);
• physical examination (proteinuria, bile pigments in large quantities);
• · coagulogram (reduction of clotting factors, created by the liver);
• · markers of viral hepatitis (increasingly negative);
• Ultrasound of the abdominal organs (enlargement of the liver, its seal);
• · FEGDS (can be determined by esophageal varicose veins of the esophagus);
• Spiral CT and MRI;
• · liver biopsy.

Toxic liver damage – Types of disease

Depending on the nature of the flow of toxic liver can be acute and chronic. There are three degrees of severity of this pathology. On morphological grounds and the nature of the defeat emit such forms of toxic liver disease: with a picture of hepatitis (Acute, chronic persisting, Autoimmune, Lobular), with Cholestasis, with the development of liver failure, with fibrosis, other violations or defeat the toxic damage, unspecified..

Toxic liver damage – Actions of the patient

If you have any of the previously listed symptoms, we recommend that you consult a specialist.

Toxic liver damage – Treatment

Treatment of toxic lesions should be complex and include: termination of impact factor toksigennogo, diet therapy, application specific antidotes (If you have them), hepatoprotectors, conduct detoxification activities, reception of proteolysis inhibitors, antibiotics, antihistamine and other necessary preparations, appointed attending physician. The ineffectiveness of conservative therapy are resorting to surgical methods (usually, liver transplantation).

Toxic liver damage – Complications

The most severe toxic to liver complications are hepatic failure with the outcome in the liver coma, cirrhosis of the liver, systemic infections, gepatocellûlârnaâ cancer, hepatorenal syndrome, infertility, as well as the defeat of other organs and systems (respiratory, The DIGESTIVE TRACT, etc.).

Toxic liver damage – Prevention

Avoid the harmful effects of any hepatotoxic substances and factors, eat rationally, Maintain a healthy lifestyle.