Tizanidin

When ATH:
M03BX02

Characteristic.

White or slightly yellowish crystalline powder.

Pharmacological action.
Miorelaksiruyuschee, central.

Application.

Painful muscle spasms in the diseases of the spine, (including osteochondrosis, spondylosis, siringomieliju, hemiplegia, cervical and lumbar syndromes), after surgery for a herniated intervertebral disc or osteoarthritis of the hip, spasticity and pain, due to neurological diseases: multiple sclerosis, Chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents, stroke, traumatic brain injury, cerebral paralysis, spasms of central origin.

Contraindications.

Hypersensitivity, severe deficiency of the liver and kidneys, pregnancy, lactation (at the end of treatment), childhood.

Side effects.

Drowsiness, feeling tired, golovokruženie or vertigo, muscular weakness, alarm, sleep disorders, hallucinations, a slight decrease in blood pressure (at low doses) or hypertension, bradycardia, dry mouth, nausea, gastrointestinal disorders, a temporary increase in serum transaminases.

Cooperation.

Antihypertensive drugs, including diuretics, enhance hypotension and bradycardia. Alcohol and sedatives deepen deprimiruyuschie effect.

Overdose.

Symptoms: nausea, vomiting, hypotension, dizziness, mioz, respiratory failure, coma.

Treatment: gastric lavage, administration of activated charcoal, diurez, maintaining vital functions.

Dosing and Administration.

Inside, 2-4 mg 3 once a day, in severe cases - further 2-4 mg at night. When neurologically caused by spastic states initial dose should not exceed 6 mg per day 3 receiving with a gradual increase of 2-4 mg, at intervals of 3-4 days - up to a week. Optimal therapeutic effect is usually reached at a dose of 12-24 mg per day in 3-4 divided doses at regular intervals (no more 36 mg per day).

Precautions.

Requires periodic monitoring of liver and kidney function, and reduction in the dose of their deterioration. Continuous increase in transaminases levels require discontinuation. Because of possible drowsiness and weakness it is recommended to limit the appointment of persons, whose work requires quick physical and mental reactions (operators, Drivers of vehicles, etc.).