TIMOGEN (Cream for external application)
Active material: timogen
When ATH: L03A
CCF: Immunostimulatory drug, improves tissue regeneration, for outdoor use
ICD-10 codes (testimony): L08.0, L20.8, L30.3, T14.0, T14.1, T30
At KFU: 14.01.06
Manufacturer: MBNPK TSITOMED Company (Russia)
Pharmaceutical form, composition and packaging
◊ Cream for external application 0.05% white or white with a yellowish tint.
| 100 g | |
| timogen (α-glutamyl-tryptophan, sodium salt) | 50 mg |
Excipients: Oil vaseline, vaseline, polioksiэtilen sorbitan monostearate (polysorbate 60), glycerol, sorbitan monostearate, stearyl alcohol, cetyl alcohol, diethylene glycol monoethyl ether, metilparagidroksiʙenzoat (nipagin), Xanthan Gum, propilparagidroksibenzoat (nipazol), Purified water.
20 g – aluminum tuba (1) – packs cardboard.
20 g – jars, glass (1) – packs cardboard.
30 g – aluminum tuba (1) – packs cardboard.
30 g – jars, glass (1) – packs cardboard.
Pharmacological action
Immunostimulatory drug. It is a dipeptide, affect the reaction cell, humoral immunity and nonspecific defense. It stimulates the regeneration processes in the event of their oppression, improve processes for cell metabolism.
Activity Increases 5 ektonukleatidazy and expression of Thy-1 is on thymocytes, providing an activating effect on the differentiation of lymphocytes in the thymus. The drug induces the expression of receptors on lymphocytes differentiation, normalizes the amount and ratio of lymphocyte subpopulations in patients with various immunodeficiency.
It normalizes the expression and the ratio of about- and anti-inflammatory cytokine in various diseases and pathological conditions, involving violation of immunoreactivity of the organism.
Pharmacokinetics
Pharmacokinetics preparation Timogen® He has not been studied in connection with its peptide.
Testimony
- Atopic dermatitis (incl. complicated by secondary bacterial infection);
- Chronic eczema and microbial true;
- Chronic pyoderma (incl. chronic diffuse streptoderma);
- Mechanical, thermal and chemical skin injury.
Dosage regimen
The recommended daily dose – 2 g cream (1000 g timogena). The drug is applied thinly to the affected area 1-2 times / day (in the morning and in the evening). After applying the cream affected area should not close a bandage.
Band of cream from a tube diameter 5 mm and length 4 see a lot of 1 g.
Course Length: before remitting the local manifestations of the disease, but not more 20 Nights.
Side effect
Maybe: allergic reactions.
Contraindications
- Pregnancy;
- Lactation (breast-feeding);
- Hypersensitivity to the drug.
Pregnancy and lactation
Contraindicated during pregnancy and lactation (breast-feeding).
Cautions
The results of the clinical studies show, Timogen the drug in the dosage form meets cream, requirements for the external therapy in chronic dermatoses (atopic dermatitis, strofulyus, microbial eczema and pyoderma) children. The drug suppresses inflammation in the outbreak, reducing swelling and flushing of the skin, reduces itching, It contributes to the rapid recovery of the integrity of the skin and eliminates dryness, thereby improves the barrier function of the skin. Besides, providing immunocorrective action, Timogen increases the protective function of the skin.
Overdose
Overdose timogena® not described. Experimentally proved, that the drug is not toxic in the doses, exceeding the therapeutic thousands of times.
Drug Interactions
Interactions with other drugs have been observed.
Conditions of supply of pharmacies
The drug is resolved to application as an agent Valium holidays.
Conditions and terms
List B. The drug should be stored out of reach of children, dark place at a temperature of 2 ° to 20 ° C.
Shelf life – 2 year.
