Thioproperazine
When ATH:
N05AB08
Characteristic.
Piperazine phenothiazine.
Pharmacological action.
Neuroleptic, antipsychotic.
Application.
Schizophrenia (particularly disorganized and continuously flowing catatonic form), Chronic hallucinatory psychosis, mania, polymorphic attacks of delirium.
Contraindications.
Hypersensitivity, toxic agranulocytosis history, zakrыtougolynaya glaucoma, prostate adenoma, parkinsonizm, organic CNS.
Restrictions apply.
Liver disease, kidney and cardiovascular system in the stage of decompensation, epilepsy (reduced seizure threshold), advanced age (because of increased sensitivity), childhood.
Pregnancy and breast-feeding.
During pregnancy should avoid prolonged use and reduce the dosage before delivery; necessary monitoring nevrologicheskoy simptomatikoy and pishtevaritelynoy sistemoy novorozhdennыh.
Side effects.
From the nervous system and sensory organs: akinesia and hyperkinesia combination with high or normal muscle tone, pozdnyaya dyskinesia (long-term treatment), akathisia, oculogyric crises, drowsiness, insomnia, apathy, alarm, mood swings, paleness, dizziness.
Cardio-vascular system and blood (hematopoiesis, hemostasis): abnormal heart rhythm, agranulocytosis.
From the digestive tract: nausea, vomiting, diarrhea, dry mouth, constipation.
Other: oligourija, urinary retention, hot flushes, teardrop- and drooling, Parez akkomodacii, Sweating, impotence, frigidity, menstrual irregularities, amenorrhea, galactorrhea, gynecomastia, hyperprolactinemia, weight gain, cholestatic jaundice, seborrhea, greasiness of the face, photosensitivity, allergic reactions.
Cooperation.
Enhances hepato- and nephrotoxicity drugs, the effects of changes (it is not recommended to combine) levodopa, guanethidine, antihypertensive drugs, morfina, antihistamines, ʙarʙituratov, trankvilizatorov, anticholinergics, incl. atropine and alcohol.
Overdose.
Symptoms: extrapyramidal disorders, low blood pressure, coma, respiratory depression, shock.
Treatment: symptomatic: IVL, introduction of plasma-liquids, central holinoblokatorov. No specific antidote.
Dosing and Administration.
Inside. Dose selected individually. The initial dose - 5 мг/сут с последующим увеличением на 5 мг каждые 2–3 дня, средняя суточная доза — 30–40 мг, if necessary - up 90 mg / day. After the relief of symptoms gradually reduce the dose to the minimum maintenance. The dose for i / m administration must not exceed 50% of the oral dose.
Precautions.
With the development of hyperthermia treatment immediately cease thioproperazine. With the development of tardive dyskinesia receiving anticholinergic antiparkinsonian contraindicated, tk. possible deterioration. Transport drivers and those, working with machinery, you need to keep in mind, that the drug may cause drowsiness (especially early in treatment).
