Testosterone
When ATH:
G03BA03
Characteristic.
In medical practice used in the form of esters, incl. testosterone propionate and testosterone undecanoate. Testosterone Propionate - white or almost white crystalline powder, practically insoluble in water, dioxane solution, and vegetable oils, rectify (1:5) and absolute (1:6) alcohol, xloroforme (1:2), ether (1:100). Molecular weight 344,5.
Testosterone undecanoate - molecular weight 444,7.
Pharmacological action.
Androgenic, antitumor, anabolic.
Application.
Androgen deficiency in men: delayed puberty, oligospermatism, post-castration syndrome, underdevelopment of genitals, gipopituitrizm, Infertility in violation of spermatogenesis, menopause, impotence, osteoporosis.
Women: hyperestrogenism, hysteromyoma, endometriosis, climacteric (in combination with estrogens), premenstrual tension syndrome, mammary cancer, osteoporosis.
Contraindications.
Hypersensitivity, or suspected carcinoma of the prostate and / or breast cancer, nephrosis or the nephrotic phase of nephritis, hypercalcemia, swelling, the liver and kidneys, diabetes, prostatic hypertrophy with voiding symptoms, cardiac and coronary insufficiency, myocardial infarction, atherosclerosis in elderly men, pregnancy, lactation.
Side effects.
Adrenarche, abnormalities and prostate cancer, increased sexual arousal and more frequent erections, penis enlargement, priapism, oligospermatism, decrease in the volume of ejaculate, sodium and water retention, premature closure of growth zones bones; headache, depression, alarm, sleep disturbance, paresthesia, bleeding in the gastrointestinal tract, nausea, cholestatic jaundice, Other androgenic effects (incl. girsutizm, seborrhea, acne).
Cooperation.
Increases effect of anticoagulants (warfarin, nikumalon, fenilin) and hypoglycemic agents, Cyclosporine inhibits the excretion. Barbiturates and alcohol decrease action.
Dosing and Administration.
Inside (capsules); / m, n / a (oily solutions of individual esters or combinations thereof). The dosage regimen is selected individually, depending on the disease, gender, age and dosage forms.
Precautions.
When side effects of androgen treatment should be stopped before they disappeared and resume reduced doses.
Cooperation
| Active substance | Description of interaction |
| Glibenclamide | Against the background of testosterone may increase the effect; combined use requires continuous monitoring of blood glucose. |
| Insulin dvuhfaznыy [human genetic engineering] | Against the background of the effect of testosterone may be increased; the combined appointment requires monitoring of blood glucose. |
| Insulin soluble [pork monocomponent] | Against the background of the effect of testosterone may be increased; the combined appointment requires monitoring of blood glucose. |
| Metformin | Against the background of testosterone may increase the effect; combined use requires continuous monitoring of blood glucose. |
| Cyclosporine | FKV. Against the background of testosterone slows down. |
| Ethanol | Reduces effect; at the time of treatment should abandon spirits. |
