TERALÏDJEN
Active material: Alimemazin
When ATH: N05AA
CCF: Antipsychotic drug (anxiolytic)
ICD-10 codes (testimony): F32, F40, F41.2, F45.3, F48.0, F51.2
When CSF: 02.01.01.01
Manufacturer: VALENTA PHARMACEUTICALS OAO (Russia)
Pharmaceutical form, composition and packaging
Pills, Film-coated dark pink, with the embossed symbol on one side and stripes on the other.
| 1 tab. | |
| alimemazina tartrate | 5 mg |
Excipients: lactose, colloidal silicon dioxide, refined sugar (sucrose), wheat starch, tapioca starch (tapioca), talc, magnesium stearate.
The composition of the shell: gipromelloza, macrogol 6000, Titanium dioxide, dye Osprej R110 pink, talc.
25 PC. – packings Valium planimetric (1) – packs cardboard.
25 PC. – packings Valium planimetric (2) – packs cardboard.
Pharmacological action
Antipsychotic drug (anxiolytic). Provides antigistaminnoe, antispasmodic, serotoninblokirtee, moderate Alfa-adrenoblokirtee, antiemetic, snotvornoe, sedative and antitussive effect.
Antipsychotic effect due to blockade of dopamine D2-receptors and the mesolimbic system Mesocortical. Has a low antipsihoticescoy activity, Therefore, when acute psychotic conditions is ineffective.
Sedative effect due to blockade of adrenergic receptors of the reticular formation of the brain stem.
Antiemetic effect due to blockade of dopamine D2-receptor trigger zone of the vomiting center.
Gipotermicescoe effect blockade dopaminovykh receptors in the hypothalamus.
In connection with good tolerance applied in child, teenage and gerontological practice.
Pharmacokinetics
Absorption
Ingestion rapidly and completely absorbed from the digestive tract. Cmax plasma is a 1-2 no.
Distribution
Plasma protein binding 20-30%.
Metabolism
A metabolite is formed – sulfoxide.
Deduction
Presented as a metabolite in urine (70-80%) during 48 no. T1/2 is 3.5-4 no.
Testimony
— neuroses and neurozopodobne of endogenous and organic Genesis-dominated senestopaticheskih, hypochondriacal, phobic disorders and psychovegetative;
— astenicheskimi psychopathy and psihoastenicheskimi disorders;
-anxiety-depressive state within the border of endogenous and vascular diseases;
— senestopaticalkie depression;
— somatizirovanne psychiatric disorders;
— State of excitement and anxiety in somatic diseases;
— sleep disturbance different Genesis;
- Allergic reactions (symptomatic treatment).
Dosage regimen
The drug is taken orally, distributing daily dose on 3-4 admission.
The onset of action of the drug – through 15-20 m, duration – 6-8 no.
Adults to achieve a hypnotic effect on 5-10 mg / day; to achieve the anxiolytic effect on 60-80 mg / day.
Babies with 7 years (Depending on the age and body mass index) to achieve a hypnotic effect on 2.5-5 mg / day; as a symptomatic treatment of allergic reactions to 5-20 mg / day; to achieve the anxiolytic effect on 20-40 mg / day; in psychotic conditions may increase the daily dose of the drug to 60 mg / day.
Side effect
From the central and peripheral nervous system: drowsiness, slackness, fatigue (there, mainly, in the early days of admission and rarely require the preparation), paradoxical reaction (anxiety, excitation, nightmares, irritability); rarely – confusion, extrapyramidal disorder (gipokineziya, akathisia, tremor); increased frequency of sleep apnea, increase in seizure activity (children).
From the senses: blurred vision (Parez akkomodacii), noise or ringing in the ears.
Cardio-vascular system: dizziness, decrease in blood pressure, tachycardia.
From the digestive system: dry mouth, atonic gastrointestinal tract, constipation, decreased appetite.
The respiratory system: dry nose, glotke, increasing the viscosity of bronchial secretions.
From the urinary system: atonic bladder, urinary retention.
Other: allergic reactions, suppression of bone marrow hematopoiesis, increased perspiration, muscle relaxation, photosensitivity.
The drug is usually well tolerated by patients. Side effects are rare and are expressed slightly.
Contraindications
- Zakrыtougolynaya glaucoma;
- Prostatic hyperplasia;
- Severe liver disease;
- Severe kidney disease;
-Parkinson's disease;
- Myasthenia;
Reye-syndrome;
- Simultaneous use of MAO inhibitors;
- Pregnancy;
- Breastfeeding;
- Children up to age 7 years;
- Hypersensitivity to the drug.
FROM caution You should use the drug in chronic alcoholism, If there are indications the disease complications in applying drugs fenotiazinovogo stimulants, When obstruction of the bladder neck, predisposition to delay incontinence, epilepsy, open-angle glaucoma, jaundice, suppression of bone marrow function, hypotension.
Pregnancy and lactation
Do not use this drug during pregnancy and breastfeeding.
Cautions
In long-term care should be systematically General blood analysis, to assess liver function.
Alimemazine may mask the ototoxic effect (noise in ears, dizziness) jointly used medicines.
To prevent distortion of the skin skarifikih samples for allergens should repeal product for 72 h to prick test.
During the period of treatment possible false positive pregnancy test results.
During the period of treatment should not be used with alcohol.
In connection with good tolerance applied in child, teenage and gerontological practice.
Effects on ability to drive vehicles and management mechanisms
Against a backdrop of drug treatment should not engage in activities, require high concentration.
Overdose
Symptoms: depression of consciousness, increased adverse reactions.
Treatment: symptomatic.
Drug Interactions
Alimemazine enhances the effect of opioid analgesics, hypnotics, anccioliticakih (trankvilizatorov) and antipsychotic (neuroleptics) drugs, as well as drugs for general anesthesia, m-holinoblokatorov and gipotenziveh drugs. You must adjust the dose alimemazina together with the use of the above-mentioned drugs.
If you are applying to alimemazina derivatives amphetamine, m-holinomimetikami, ephedrine, guanethidine, levodopa, dopamine is weakened by recent activity.
If you are applying to alimemazina with ethanol and drugs, suppress the CENTRAL NERVOUS SYSTEM, There is oppression CNS.
If you are applying to alimemazina with antiepileptic drugs and barbiturates reduces threshold sudorojna preparedness (a correction dose).
If you are applying to alimemazina with beta-adrenoblokatorami concentrations recent plasma (perhaps marked reduction of blood pressure, Arrhythmia).
If you are applying to alimemazina with bromkriptine the last action is waning, and raises the concentration of prolactin in serum.
If you are applying to alimemazina with tricyclic antidepressants and anticholinergic drugs increasing m-holinoblokirujushhej activity alimemazina.
If you are applying with alimemazina MAO inhibitors and fenotiazina derivatives increased risk of arterial hypertension and extrapiramidale disorders (concurrent use is not recommended).
Together with the use of alimemazina drugs, suppress bone marrow hemopoiesis, increased risk of mielosupression.
If you are applying to alimemazina with gepatotoksicskimi medicines amplified manifestations of drug hepatotoxicity.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.
