Active material: Paracetamol, Pheniramine, Phenylephrine
When ATH: N02BE51
CCF: The drug for the symptomatic treatment of acute respiratory diseases
When CSF: 03.02.01.03
Manufacturer: NOVARTIS CONSUMER HEALTH S.A. (Switzerland)
Pharmaceutical form, composition and packaging
| ◊ Powder for oral solution (berries) | 1 again. |
| paracetamol | 325 mg |
| pheniramine maleate | 20 mg |
| phenylephrine hydrochloride | 10 mg |
sucrose, acesulfame potassium, charming red dye (E129) (dye FD&C Red №40), dye brilliant blue (E133) (dye FD&C blue №1), maltodextrin M100, silicon dioxide, natural raspberry flavor WONF Durarome (860385 TD0994), natural cranberry flavor Durarome (861149 TD2590), lemon acid, sodium citrate dihydrate, calcium phosphate, magnesium stearate.
11.5 g – packets of the composite material (10) – packs cardboard.
Pharmacological action
Combination tool; has antipyretic, analgesic, vasoconstrictor, antihistamine, sedation, antitussive and bronchodilatory effect; eliminates the symptoms “colds”. Pseudoephedrine causes vasoconstriction, reduces puffiness, local exudative manifestations and congestion of the nasal mucosa, nasopharynx, paranasal sinuses. Paracetamol – Non-narcotic analgesics, It has analgesic, antipyretic and anti-inflammatory action of weakly expressed. Xlorfenamin – blocker of H1-histamine receptors, It has antiserotoninovoe, antihistamine, weak anticholinergic, sedation, It reduces the severity of allergic reactions, mediated through the action of histamine, reduces the permeability of capillaries, constricts blood vessels, eliminates swelling and congestion of the nasal mucosa, nasopharynx and paranasal sinuses; reduces local exudative manifestations, suppresses the symptoms of allergic rhinitis: chikhaniye, rhinorrhea, itchy eyes, nose. Valid – through 20-30 m, duration – 4-4.5 no.
Testimony
“Colds” and infectious diseases with fever; rhinitis, rhinorrhea, sinusitis, rinofaringit, nasal allergy, rhinosinusopathy, vasomotor rhinitis, pollen disease.
Contraindications
Hypersensitivity; pregnancy, lactation; childhood (to 12 years).C care. Deficiency of glucose-6-fosfatdegidrogenazы; blood disease, liver and / or kidney failure, zakrыtougolynaya glaucoma, prostatic hyperplasia; congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), related heart disease, arterial hypertension, thyroid disease, diabetes, emphysema, chronic bronchitis.
Side effects
Hypererethism, dizziness, sleep disorders, nausea, vomiting, epigastric pain; allergic reactions: skin rash, itch, angioedema; dry mouth, urinary retention, Parez akkomodacii, midriaz, increased intraocular pressure; anemia, thrombocytopenia, pancytopenia; gemoliticheskaya anemia, aplasticheskaya anemia; scarp- and nephrotoxicity (incl. papillary necrosis); bronhospazm.Peredozirovka. Xlorfenamin. Symptoms: dizziness, excitation, sleep disorders, depression, convulsions and coma. Treatment: symptomatic. Paracetamol. Symptoms (upon receiving over 10-15 g): pale skin, decreased appetite, nausea, vomiting; gepatonekroz; activity increase “Hepatic” transaminases, increased prothrombin time. Treatment: gastric lavage in the first 6 no, introduction of donators SH-groups and precursors of glutathione synthesis – through methionine 8-9 hours after the overdose and N-acetylcysteine – through 12 no. To prevent late hepatotoxicity carry out gastric lavage.
Dosing and Administration
Inside, by 1 sachet with an interval 4 no, not more 4 sachets per day. Before taking a sachet dissolved in a glass of hot water.
Cautions
During treatment is carried out control of peripheral blood and functional state of the liver. During the period of treatment should refrain from the use of ethanol (may develop hepatotoxicity), driving and occupation, etc.. potentially hazardous activities, require high concentration and speed of psychomotor reactions.
Cooperation
It enhances the effects of MAO inhibitors, sedative drugs, ethanol. Ethanol enhances the sedative effect chlorphenamine. Antidepressants, antiparkinsonian and phenothiazine antipsychotic drugs increase the risk of side effects (urinary retention, dry mouth, constipation). Corticosteroids increase the risk of glaucoma. Paracetamol reduces the effectiveness of drugs urikozuricheskih.
Xlorfenamin concurrently with MAO inhibitors, furazolidone can lead to a hypertensive crisis, excitation, giperpireksii. Tricyclic antidepressants increase the sympathomimetic effects, co-administration of halothane increases the risk of ventricular arrhythmias. Reduces hypotensive effect of guanethidine, which in turn enhances the activity of alpha-adrenostimuliruyuschee pseudoephedrine.
