TEOTARD

Active material: Theophylline
When ATH: R03DA04
CCF: Bronchodilators – a phosphodiesterase inhibitor
When CSF: 12.01.03
Manufacturer: KRKA d.d. (Slovenia)

Pharmaceutical form, composition and packaging

Excipients: diʙutilftalat, Colloidal anhydrous silica, ammonium methacrylate copolymer type B, ammonium methacrylate copolymer type A, povidone, talc.

Ingredients of the capsule shell: gelatin, Indigo carmine dye (E132), Titanium dioxide (E171), quinoline yellow dye (E104).

10 PC. – packings Valium planimetric (4) – packs cardboard.

[Ring] diʙutilftalat, Colloidal anhydrous silica, ammonium methacrylate copolymer type B, ammonium methacrylate copolymer type A, povidone, talc.

Ingredients of the capsule shell: gelatin, Indigo carmine dye (E132), Titanium dioxide (E171), quinoline yellow dye (E104).

10 PC. – packings Valium planimetric (4) – packs cardboard.

Pharmacological action

Teotard affects various body functions. It has a stimulating effect on the central nervous system, although less pronounced, than caffeine; increases the contractile activity of the myocardium (heart muscle). Several expands peripheral, coronary (heart) and renal vessels, It has a mild diuretic (diuretic) action, inhibits aggregation (anti-adherents) Platelet, inhibits the release of mast cell mediators of allergy. Particularly important is the ability to provide teotarda bronhorasshiryayushy effect. The mechanism of action of teotarda play a role inhibition of phosphodiesterase and accumulation in the tissues of cyclic adenosine monophosphate 3-5. CAMP accumulation in cells of the compound inhibits actin-myosin, which reduces the contractile activity of smooth muscle (muscle vessels and internal organs) and promotes, in particular, relax bronchial and lifting bronchospasm (bronchoconstriction). To relax muscles teotarda ability to inhibit transport of calcium ions across “slow” Channels cell membranes. Of particular importance in the molecular mechanism of action is revealed in teotarda posledstviidnee time in its ability to block adenosine (purine) receptors.

Dosing and Administration

During the first 3 days to be taken by 1 capsule every 12 hours. On the third day must evaluate the efficacy and tolerability of the product. If a good therapeutic effect and tolerability of the product should continue its application, without changing the dosage. In case of insufficient effectiveness of the dosage can be increased. Teotard 200 administered to children, weight exceeding 20 kg. Teotard 350 appointed to adults and children, mass exceeds 40 kg. Teotard 500 given to patients, the treatment of which require high dosage of the product. If the patient complains mainly on night attacks, then it can be assigned to only one capsule teotard 500 before bedtime. Morning and evening dosing of the product may be different depending on the rate of occurrence of asthma attacks. The capsules of the product should not be opened or chewed.

Contraindications

Teotard contraindicated if you are hypersensitive, hyperfunction (increased activity) Thyroid, acute myocardial infarction, subaortic stenosis (non-inflammatory disorder of muscle tissue of the left ventricle, characterized by a sharp narrowing of the cavity), arrythmia (heart rhythm disturbances), epilepsy and other convulsive states, pregnancy. Caution must be observed in gastric ulcer and duodenal ulcer.

Drug Interactions

It increases the likelihood of side effects of GCS, ISS (gipernatriemiya), funds for general anesthesia (increased risk of ventricular arrhythmias), means, central nervous system stimulants (increases neurotoxicity). Antidiarrhoeal products and chelators reduce the absorption of theophylline. Rifampicin, phenobarbital, phenytoin, Isoniazid, Carbamazepine, sulfinpirazon, aminoglutethimide, oral contraceptives and moratsizin estrogensoderzhaschie, As inducers of microsomal oxidation, increase the clearance of theophylline, which may require increasing the dose. When using P450 inhibitors (incl. macrolide antibiotics, lincomycins, allopurinolom, cimetidine, ftorxinolonami), isoprenalin, enoxacin, disulьfiramom, recombinant interferon alpha, metotreksatom, mexiletine, propafenone, tiaʙendazolom, ticlopidine, verapamil and influenza vaccination potency of theophylline may increase demand and reduce the dose. It enhances the effect of beta-agonists, and diuretics (incl. by increasing the glomerular filtration), reduces the effectiveness of the products Li + and beta-blockers. Compatible with antispasmodics, is not used in conjunction with other. xanthine derivatives. Precautions appointed concurrently with anticoagulants.

Side effects

In some cases, there are side effects: heartburn, nausea, vomiting, diarrhea, headache. When poor tolerability of the product cancel. In case of overdose can occur epileptoid teotarda (convulsive) seizures. In order to prevent these side effects is not recommended long teotard.

Storage conditions

List B. Dry, protected from light.
Shelf life – 5 years.