Tenoxican
When ATH:
M01AC02
Pharmacological action.
Anti-inflammatory, pyretic, analgesic.
Application.
Inflammatory and degenerative diseases of the musculoskeletal system, accompanied by pain: articular syndrome in gout, rheumatoid arthritis, osteoarthritis, ankiloziruyushtiy spondylitis, osteochondrosis; Tendinitis, ʙursit, myositis; pain in the spine, neuralgia, myalgia, injury.
Contraindications.
Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (incl. history), gastrointestinal bleeding (incl. history), severe gastritis, "Aspirinovaâ" triad (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses, and intolerance of aspirin and drugs pirazolonovogo series), coagulation failure, expressed human liver and / or kidney.
Restrictions apply.
Diabetes, arterial hypertension, congestive heart failure, pregnancy, lactation, childhood.
Side effects.
From the digestive tract: dyspepsia (nausea, vomiting, heartburn, diarrhea, flatulence), NSAID-gastropathy, pain and discomfort in the abdomen, stomatitis, anorexia; long-term use at high doses - erosive and ulcerative lesions of the gastrointestinal tract.
From the nervous system and sensory organs: headache, dizziness, insomnia, depression, hypererethism, swelling and irritation of the eyes, blurred vision, hearing loss, noise in ears.
Cardio-vascular system and blood (hematopoiesis, hemostasis): tachycardia, edematous syndrome, increased blood pressure, bleeding (gastrointestinal, gingival, Royal, hemorrhoidal), leukopenia, agranulocytosis.
Allergic reactions: skin rash, hives, itch, эritema, sindromy Stevens-Johnson and Lyell.
Other: impairment of renal function, increase plasma concentrations of creatinine, BUN, bilirubin and liver transaminases, prolonged bleeding.
Cooperation.
Do effects (incl. toxic) lithium preparations, anticoagulants, oral hypoglycemic agents (sulfonylurea derivatives), side effects of mineralogy- and glucocorticoids, estrogen. Antacids reduce the absorption rate. Other NSAIDs increase the risk of adverse events, especially from the gastrointestinal tract. Myelotoxic drugs increase the expression gematotoksichnosti.
Dosing and Administration.
Inside, / m, I /. Inside, at the same time of the day, with water or other liquid, dose 20 mg 1 once a day; maintenance dose - 10 mg / day. In acute gout attacks - on 40 mg 1 once a day for the first 2 days, then - 20 mg 1 once a day for 5 days. Elderly patients administered at a dose of 20 mg / day.
Precautions.
To use caution in the treatment of older people, against the backdrop of diuretics, nephrotoxic drugs, immediately after surgery. A few days before surgery should be canceled tenoxicam. During long-term treatment is necessary to monitor liver and kidney function, prothrombin index (against the background of indirect anticoagulants), glucose (If the patient receives oral hypoglycemics). Development during the treatment of erosive and ulcerative lesions and bleeding from the gastrointestinal tract requires immediate discontinuation of the drug and take appropriate action.
When used in conjunction with diuretics and in patients with hypertension and congestive heart failure should consider the possibility of sodium and water retention in the body. It must be borne in mind, that a history of kidney disease predisposes to the development of interstitial nephritis, papillary necrosis and nephrotic syndrome.
