Tegafur

When ATH:
L01BC03

Characteristic.

Antimetaʙolit, derivative of fluorouracil.

The white crystalline powder;. It is soluble in water and ethanol, practically insoluble in chloroform and ether, sodium salt is soluble in water, pH 1% solution 4,5-5,0.

Pharmacological action.
Antitumor, cytostatic.

Application.

Stomach cancer, kolorektalynыy cancer, liver cancer (hepatocellular and metastatic), Breast, Uterine and ovarian, bladder and prostate, Head and Neck, lymphoma skins, atopic dermatitis, endogenous uveitis (phonophoresis).

Ointment: yzъyazvyvshayasya bazalyoma.

Contraindications.

Hypersensitivity, terminal illness, suppression of bone marrow hematopoiesis, pronounced changes in the blood, anemia, leukopenia (меньше 3·10⁹/l), thrombocytopenia (меньше 100·10⁹/l), gemorragija, severe infection, gastric ulcer and duodenal ulcer, the risk of bleeding in the gastrointestinal tract, liver and kidney dysfunction.

Method fonoforeza: hypotension eyes, retinal disinsertion, disease, that preclude treatment with ultrasound.

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: confusion, drowsiness, ataxia, euphoria, diplopia, lacrimation, fibrosis of the lacrimal duct.

Cardio-vascular system and blood (hematopoiesis, hemostasis): leukopenia, thrombocytopenia, heartache, išemiâ, myocardial infarction.

From the respiratory system: sore throat, pharyngitis.

From the digestive tract: stomatitis, nausea, vomiting, anorexia, diarrhea, dyspepsia, mukozit (esophagitis, ulceration of the gastrointestinal mucosa), bleeding in the gastrointestinal tract.

For the skin: Dry epidermis, hyperemia, dryness, itch, peeling, giperpigmentatsiya (using ointment), hair loss and other disorders of skin regeneration, hair and nails.

Cooperation.

It enhances the action of other anticancer agents. Compatible with cyclophosphamide, metotreksatom, doxorubicin, mitomycin and other anticancer drugs, does not exhibit cross-resistance to tegafur. Inhibitors of microsomal oxidation in the liver increase the toxicity. Antibacterial (metronidazol) and anti-ulcer (cimetidine) means to inhibit the metabolism and increase plasma concentration, duration of action and toxicity. Able to react with weakly acidic drugs (It is a weak base) with unpredictable consequences.

Dosing and Administration.

Inside, 20-30 mg/kg (1,6-2 G) in 2 receiving intervals 12 no, Course no more 2 Sun, the average dose rate is 30-40 g (to 60 g). If necessary the re-training through 1.5-2 months.

B /, slowly, bolus or infusion, 1-2 Times a day, in the supine position (in order to avoid dizziness). The daily dose - 30 mg / kg (no more 2 g), coursework — 30-40 g.

When skin lymphoma and neurodermatitis is/in, 400 mg / day, heading dose is 4-6 g (10-15 Introduced).

Outwardly. Ointment (2-4 G) put a thin layer on the affected area of ​​the skin 2 once a day. Before each applique tumor cleaned with disinfectant (nitrofural, hydrogen peroxide, etc.). The course is 3-4 weeks, if necessary, a second course of 1-1.5 months.

Method fonoforeza (in endogenous uveitis): 4% solution, the course of treatment is 10-15 daily procedures 5 m. Treatment is carried out 2-3 times a year.

Cautions.

During treatment should regularly monitor the pattern of peripheral blood. The application is admissible no earlier than 1 Months after previous radiation or chemotherapy. With the development of deep anemia blood transfusions (100-125 Ml) 2-3 Times a week.

The drug was stopped immediately when pronounced vomiting, the appearance of stomatitis, diarrhea, faringita, ezofagita, bleeding, leukopenia (меньше 3·10⁹/l), thrombocytopenia (меньше 100·10⁹/l).

During treatment requires a thorough oral care, vitamins.

Cooperation