TARIЦIN

Active material: Ofloxacin
When ATH: J01MA01
CCF: Fluoroquinolone antibacterial drug
When CSF: 06.17.02.01
Manufacturer: Chemical-Pharmaceutical Plant JSC QUINACRINE (Russia)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Pills, Film-coated from white to white with Valium or a grayish tint.

Excipients: potato starch, Croscarmellose sodium, magnesium stearate, povidone, microcrystalline cellulose.

The composition of the shell: gipromelloza (hydroxypropyl), glycerol, lactose, macrogol (polyethylene glycol), talc, Titanium dioxide.

10 PC. – packings Valium planimetric (1) – packs cardboard.

Pharmacological action

Antibacterial drug broad spectrum fluoroquinolone. Effective bactericidal. Its mechanism of action is related to the blockade of the enzyme DNA gyrase in bacterial cells.
Highly active against most Gram-negative bacteria: Escherichia coli, Salmonella spp., Enterobacter spp., Serratia spp., Сitrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (incl. Klebsiella pneumoniae), Helicobacter pylori, Acinetobacter spp., Mycoplasma spp., Vibrio spp., Gardnerella vaginalis, Neisseria gonorrhoeae, Neisseria meningitidis, Chlamydia spp., Ureaplasma urealyticum; some Gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (especially beta-hemolytic), Mycobacterium leprae.
Taritsin active against microorganisms, producing beta-lactamase.
C drug moderately sensitive: Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp.
Tariцin inactive against most anaerobic bacteria, as well as against Treponema pallidum.

Testimony

Treatment of infectious and inflammatory diseases, caused by sensitive microorganisms:
- Respiratory tract infections (except pneumococcus);
- Infections of upper respiratory tract (except acute tonsillitis);
- Infections of the abdominal cavity;
- An infection of the liver and biliary tract;
- Kidney infection, prostate, urinary tract (incl. gonococcal nature);
- Gynecological infections;
- Bone and joint infections;
- Infections of the skin and soft tissues.

Dosage regimen

The dose and duration of treatment depends on the severity and type of infection, the general condition of the patient and kidney function.
Average daily dose for adults It is between 200 mg 600 mg. Duration of treatment 7-10 days. The daily dose to 400 Recommend mg administered in 1 reception, better in the morning.
When treating uncomplicated infections of the lower urinary tract Taritsin prescribe a dose 200 mg / day.
At severe infections, as well as in the treatment of patients with overweight the daily dose can be increased to 600 mg.
In patients with impaired renal function the dose should be reduced depending on the creatinine clearance.

In patients with impaired liver function Do not exceed the maximum daily dose 400 mg.
Tablets should be taken as a whole, with a glass of water before, and during meals.

Side effect

Allergic reactions: skin rash, itch, hives, photosensitivity, angioedema, bronchospasm, weakness; rarely- anaphylactic shock; in a few cases – erythema multiforme, Stevens-Johnson syndrome, toxic skin necrosis, purpura.
From the digestive system: abdominal pain, anorexia, nausea, vomiting, diarrhea; rarely – transient increase in bilirubin and liver enzymes in the blood plasma; in a few cases – hepatitis. There is a risk of pseudomembranous colitis.
CNS: decrease in the rate of mental reactions, headache, dizziness, sleep disturbance, generalized weakness; in some cases – lack of movement, tremor, muscle cramps, numbness and paresthesias in extremities, nightmares, psychotic reactions in the form of anxiety, excitation, fear, depression, confusion, visual and auditory hallucinations, incoordination; diplopia, violation of color, taste disturbances, olfactory, hearing and balance.
From the hematopoietic system: leukopenia, agranulocytosis, thrombocytopenia, eozinofilija; in a few cases – gemoliticheskaya anemia, pancytopenia.
From the urinary system: in some cases – acute interstitial nephritis or breach azotovydelitelnoy function with some increase in urea and creatinine.
Cardio-vascular system: tachycardia.
Other: arthralgia, myalgia, tendinitы, gipoglikemiâ (patients with diabetes).

Contraindications

- Epilepsy;
- CNS, accompanied by a lowering of the threshold of convulsive readiness, (after head injury, stroke, inflammation in the CNS);
- Pregnancy;
- Lactation (breast-feeding);
- Childhood and adolescence up 18 years;
- Hypersensitivity to ofloxacin and other fluoroquinolones.

Pregnancy and lactation

Taritsin is contraindicated during pregnancy and lactation.
IN experimental studies monoftorhinolonov found toxic effects on cartilage.

Cautions

Because of possible photosensitivity during treatment Taritsinom avoid UV radiation.
In case of signs of tendinitis (especially in elderly patients) should immediately stop treatment, produce immobilization, Achilles tendon and consult a podiatrist.
In case of side effects, especially the central nervous system, or allergic reactions, Taritsin should be abolished.
If you experience while taking Taritsina severe and prolonged diarrhea, development-related pseudomembranous colitis, the drug should be immediately withdrawn and therapy, comprising oral vancomycin and metronidazole.
Application Taritsina can lead to worsening of myasthenia gravis. Perhaps more frequent attacks of porphyria in predisposed patients.
Ofloxacin inhibits release of Mycobacterium tuberculosis, leading to false-negative results in the bacteriological diagnosis of tuberculosis.
Precautions should be prescribed to patients Taritsin, predisposed to seizures (incl. CNS trauma history).
The interval between doses Taritsina and taking antacids or iron preparations should be about 2 no.
In an application Taritsina and vitamin K antagonists need to control blood clotting time.
Effects on ability to drive vehicles and management mechanisms
While taking Taritsina may impair the capacity of the patient to the concentration and speed of psychomotor reactions. Slowing the rate of reaction is exacerbated by alcohol while taking.

Overdose

Symptoms: dizziness, confusion, vomiting.
Treatment: gastric lavage; if necessary – simptomaticheskaya therapy. There is no specific antidote.

Drug Interactions

In an application with antacids and iron supplements reduced the effectiveness of Taritsina.
In an application with Taritsinom possible slight increase in the concentration of glibenclamide in plasma.
In an application with Probenecid Taritsina, cimetidine, furosemide or methotrexate may increase the concentration of ofloxacin in plasma.
Receiving Taritsina not affect the plasma concentration of theophylline.

Conditions and terms

List B. The drug should be stored in a dry, dark place at a temperature no higher than 25 ° C. Shelf life – 2 year.
Conditions of supply of pharmacies
The drug is released under the prescription.