Sulьfaguanidin

When ATH:
A07AB03

Characteristic.

The white crystalline powder odorless. Very slightly soluble in water and alkaline solutions, мало — в этаноле и ацетоне.

Pharmacological action.
Antimicrobial.

Application.

Bakterialynaya dysentery (acute, subacute, and chronic forms of carriage), typhoid carrier rods, preparation for operations on small and large intestine (prevention of septic complications).

Contraindications.

Hypersensitivity (incl. to other sulfonamides), toxic and allergic reactions to sulfonamides history, giperʙiliruʙinemija (children), deficiency of glucose-6-fosfatdegidrogenazы, urolithiasis disease, B₁₂-defitsitnaya anemia, pregnancy, lactation, ages newborn and chest.

Side effects.

Kristallurija, dyspepsia, nausea, vomiting, deficiency of B vitamins, leukopenia, neuritis, allergic reactions (hives, exfoliative dermatitis and others.).

Cooperation.

Benzokain, procaine reduce antimicrobial activity (upon hydrolysis release PABA). NSAIDs, antidiabetic drugs (sulfonylureas), phenytoin, coumarin anticoagulants increase side (System) effects (displaced from binding with plasma proteins and increase the concentration of the free fraction of blood), метенамин и аскорбиновая кислота — вероятность развития и выраженность кристаллурии (increase the acidity of urine). Reduces the reliability of oral contraceptives.

Dosing and Administration.

Inside. In acute dysentery conducted two cycles of treatment. First course: 1–2-й день — 6 g per day (1 g every 4 no), 3-й и 4-й день — 4 g per day (1 g every 6 no), 5–6-й день — 3 g per day (1 g every 8 no). На курс — 25–30 г. After 5-6 days, by a second cycle: 1–2-й день — 5 g per day, by 1 g in 4 no (by night 8 no), 3–4-й день — 4 g per day, 1 g in 4 no (night do not give), 5-й день — 3 g per day. Общая доза на второй курс — 21 g, при легком течении — 18 g. Babies: до 3-х лет — 0,2 г/кг в сутки в 3 admission; старше 3-х лет — по 0,4 - 0,75 g 4 twice a day for 7 days. In the treatment of other infections: взрослым — в первые 2–3 дня по 1–2 г каждые 4–6 ч, в следующие 2–3 дня — половинные дозы; детям — 1-й день по 0,1 г/кг в сутки, равными дозами каждые 4 no, в следующие дни — по 0,2–0,5 г каждые 6–8 ч. For the prevention of postoperative complications: by 0,05 g / kg every 8 h for 5 days before and 7 days after surgery.

Higher doses for adults inside: single - 2 g, daily - 7 g.

Precautions.

To prevent crystalluria patients should receive plenty of alkaline water (2-3 Liters per day). At the same time recommended the B vitamins.

Should strictly abide by dose regimen, tk. otherwise (early termination of treatment failure or dose) possible emergence of resistant strains of pathogens, not amenable to further action sulfonamides.