Sulfadimidine

When ATH:
J01EB03

Characteristic.

White or slightly yellowish crystalline powder;. Practically insoluble in water, ether and chloroform, slightly soluble in ethanol. Easily soluble in dilute acids and alkalis.

Pharmacological action.
Antimicrobial, Antibacterial, bacteriostatic.

Application.

Pneumococcal, Meningococcal, streptococcal infections, disease, caused by E. coli: sore throat, bronchitis, pneumonia, genyantritis, otitis, meningitis, inflammatory diseases of bile- and urinary tract infections, wound infection, pyoderma, gonorrhea, trachoma, mug, dysentery, toxoplasmosis.

Contraindications.

Hypersensitivity.

Restrictions apply.

Diseases of the hematopoietic system, renal dysfunction, hyperbilirubinemia in children (because of the risk of bilirubin encephalopathy), deficiency of glucose-6-fosfatdegidrogenazы (because of the risk of hemolytic crisis), pregnancy, lactation.

Side effects.

Nausea, vomiting, kristallurija, leukopenia, agranulocytosis, allergic reactions.

Cooperation.

Reduces the effectiveness of bactericidal antibiotics, It operates only on dividing microorganisms (incl. penicillins, cephalosporins). When toxoplasmosis is permissible combination with pyrimethamine. Absorption in the intestine is reduced under the influence of antacids. Against the backdrop of the simultaneous reception butadiona, sulfonylureas, phenytoin, neodikumarina and other funds with high affinity to plasma proteins sulphadimidine possible expulsion from its association with proteins and increased concentration of its free fraction of blood. High doses of ascorbic acid, geksametilentetramina (urotropyna) increase the risk of crystal formation. Antimicrobial activity falls in the presence of novocaine, as well as preparations, containing parabens. Increases (mutually) gematotoksichnosti hloramfenykola, merkazolila.

Dosing and Administration.

Inside - By 1 g 4-6 times per day; pneumonia and meningitis on 1 appointed reception 2 g; children - a rate 0,1 g / kg 1 reception, then - on 0,25 g / kg every 4, 6, 8 no. Higher doses for adults - single 2 g, daily 7 g; the daily dose for children under 1 year - 0,15 g / kg, senior 1 year - 0.1-0.15 g / kg; dysentery appoint scheme: 1 cycle course of treatment - 25-30 g, 2 cycle - 18-21 g.

Precautions.

The treatment shows rich alkaline water; long-term use requires systematic monitoring of blood tests.