Strophanthin-K

When ATH:
C01AC01

Characteristic.

White or white with a slightly yellowish white crystalline powder. It is soluble in water and ethanol, practically insoluble in ether and chloroform.

Pharmacological action.
Cardiac.

Application.

Acute heart failure, chronic circulatory insufficiency stage II-III, especially with the ineffectiveness of drugs digitalis, supraventricular tachycardia, fibrilloflutter.

Contraindications.

Hypersensitivity, organic lesions of the heart and blood vessels, acute myocarditis, endokardit, expressed cardiosclerosis, acute myocardial infarction, AV block II-III degrees, gipertroficheskaya obstruktivnaya cardiomyopathy and pericarditis konstriktivnыy, carotid sinus syndrome, intoxication serdechnыmi glikozidami, thyrotoxicosis, Atrial premature beats (a transition in atrial fibrillation).

Side effects.

Arrhythmia, nausea, vomiting, diarrhea, brыzheechnыy attack, headache, weakness, insomnia, depression, hallucinations, psychoses, visual disturbances, gynecomastia.

Cooperation.

Calcium antagonists (especially verapamil) and amiodarone slows down and increases plasma concentration (if necessary, joint use of dose strophanthin-K should be reduced to 2 times). Sympathomimetic, calcium salts, and antiarrhythmic agents increase the risk of arrhythmias. Against the background of magnesium sulfate increases the likelihood of reducing conductivity and AV heart block.

Overdose.

Symptoms: arrythmia, ʙigeminija, dissociation rate.

Treatment: reduction in regular doses and increasing time intervals between doses; if hypokalemia - potassium supplements; in the case of arrhythmias - lidocaine, prokaynamyd, propranolol, phenytoin, chelating agents (EDTA).

Dosing and Administration.

B /, / m, / drip, adult dose 250 ug injections followed by 100 ug / hr to a total dose of 1000 micrograms per 24 no. Pre-diluted in glucose solution or isotonic sodium chloride solution.

Precautions.

With the rapid on / in a possible development of bradyarrhythmias, Ventricular tachycardia, AV block and cardiac arrest. At the peak effect may appear beats, sometimes in the form bigeminy. For the prevention of this effect, the dose may be divided into 2-3 / in a single or divided doses administered / m. Before / m administered by injection 5 ml 2% Novocaine, then, without removing the needle - strophanthin-K; efficiency / m in applications 2 times lower. If the patient previously appointed other cardiac glycosides, you need to on / in the strophanthin-K to take a break (5-24 Days - depending on their expressed cumulative properties). Treatment is carried out under the constant supervision of the ECG.