Spectinomycin

When ATH:
J01XX04

Characteristic.

Natural antibiotic tricyclic structure. Produce Streptomyces spectabilis.

Issued in the form dihydrochloride pentahydrate. White or pale white crystalline powder. Solubility in water, methanol, propylene glycol, formamide, dimethyl sulfoxide, 0,1n. NaOH и 0,1н. HCl is more 20 mg / ml, chloroform 0,042; acetone 0,015; diethyl ether 0,010. Molecular weight 495,35.

Pharmacological action.
Antibacterial, bacteriostatic, bactericide.

Application.

Sharp gonorrheal urethritis and prostatitis in men, acute gonorrheal cervicitis and proctitis in women, caused by susceptible strains Neisseria gonorrhoeae, in case of intolerance or ineffectiveness of beta-lactam antibiotics. Prophylaxis after sexual contact with gonorrhea.

Contraindications.

Hypersensitivity, the neonatal period.

Restrictions apply.

Pregnancy, lactation.

Pregnancy and breast-feeding.

There are no adequate and well-controlled studies in pregnancy is not carried out, However spectinomycin it recommended for the treatment of gonococcal infections in pregnant women who are allergic to penicillins, cephalosporins or probenecid; in animal adverse effects on the fetus revealed no.

Unknown, Do spectinomycin penetrates into breast milk, complications in humans has not been registered.

Side effects.

From the nervous system and sensory organs: dizziness, insomnia.

From the digestive tract: dyspepsia, incl. nausea, vomiting, stomach cramps, increase in liver enzymes and alkaline phosphatase levels.

Allergic reactions: hives, itch, chills, fever, dermahemia, anaphylactic shock, and others.).

Other: oligurija, increasing the concentration of blood urea nitrogen, decrease in hemoglobin, gematokrita, creatinine clearance; tenderness at the injection site.

Dosing and Administration.

/ M. For adults: In neoslozhnennoй gonorrhea - 2 g singly or in the form of two injections at different locations (Total 4 g); when reinfection or suspected it possible to introduce second dose. For children: body weight up 45 kg dose of 40 mg / kg, above 45 kg - 2 g / m, single.

Precautions.

To prevent transmission of infection male sexual partners should use condoms. To prevent reinfection may require simultaneous treatment of a partner.

Spectinomycin is not used for pharyngeal gonorrhea.