Ointment contains
Active material: deproteinized dialysate from the blood of dairy calves
When ATH: B05ZA
CCF: Preparation, activates metabolism in tissues, improves trophic and stimulating the regeneration process
Codes ICD-10 (testimony): I61, I63, I73.0, I73.1, I73.9, I79.2, I83.2, I87.2, S06, T90
When CSF: 02.14.07
Manufacturer: VALEANT PHARMACEUTICALS SWITZERLAND GmbH (Switzerland)
Pharmaceutical form, composition and packaging
Solution for in / and the / m yellowish to yellow, clear, with a distinctive slight smell of meat broth.
| 1 ml | |
| deproteinized dialysate from the blood of dairy calves (based on the dry matter) | 42.5 mg |
Excipients: water d / and.
2 ml – vials of dark glass (5) – packings Valium planimetric (5) – packs cardboard.
5 ml – vials of dark glass (5) – packings Valium planimetric (1) – packs cardboard.
Pharmacological action
The stimulator of tissue regeneration. It is a deproteinized blood gemodializat dairy calves, containing a wide range of low molecular weight components of the cell mass and serum with molecular weight 5000 D (incl. glycoproteins, nucleosides and nucleotides, amino acids, oligopeptides).
Solkoseril improves the transport of oxygen and glucose to the cells, located under hypoxia, It enhances the intracellular synthesis of ATP and increases the dose of aerobic glycolysis and oxidative phosphorylation, activates the reparative and regenerative tissue processes, It stimulates fibroblast proliferation and collagen synthesis vessel walls.
Pharmacokinetics
Research pharmacokinetic absorption processes, distribution and elimination of the drug by standard chemical analysis methods is not possible, tk. in their composition preparation contains blood components and substances, commonly found in the body.
Testimony
Violations of peripheral arterial or venous circulation:
- Occlusive peripheral arterial disease in stage III-IV by Fontaine;
- Chronic venous insufficiency, accompanied by trophic disorders.
Violations of cerebral metabolism and blood circulation:
- Ischemic stroke;
- Hemorrhagic stroke;
- Traumatic brain injury.
Dosage regimen
The drug is introduced into / in the drip (pre-diluted 250 ml 0.9% solution of sodium chloride or 5% dextrose), in / slow (pre-diluted 0.9% solution of sodium chloride or 5% dextrose in a ratio 1:1), / m.
Occlusive peripheral arterial disease at the stage III-IV by Fontaine: in / on 20 ml daily. The duration of therapy is up 4 weeks and is determined by the clinical picture of the disease.
Chronic venous insufficiency, accompanied by trophic disorders: in / on 10 ml 3 times a week. The duration of therapy is not more than 4 weeks and is determined by the clinical picture of the disease. If you have a local trophic disorders tissue is recommended simultaneous therapy with gel Solkoseril, and then Solkoseril ointment.
Traumatic brain injury, metabolic and cerebrovascular diseases: I / 10-20 ml daily for 10 days. Further – / m or / by 2 ml to 30 days.
If / introduction impossible, the drug may be administered / m 2 ml / day.
Side effect
Allergic reactions: rarely – hives, fever.
Local reactions: rarely – hyperemia, swelling at the injection site.
Contraindications
- Childhood and adolescence up 18 years (data on the safety of the missing);
- Pregnancy (data on the safety of the missing);
- Lactation (data on the safety of the missing);
- Established hypersensitivity to bovine blood dialysate;
- Hypersensitivity to derivatives of parahydroxybenzoic acid (E216 and E218) and the free benzoic acid (E210).
FROM caution use in patients with hyperkalemia, renal failure, cardiac arrhythmias, when concomitant drug potassium (tk. Solkoseril contains potassium), when oliguria, anurii, pulmonary edema, severe heart failure.
Pregnancy and lactation
To date, no cases of unknown teratogenic effects Solcoseryl, Nevertheless, during pregnancy the drug should be used with caution, on strict conditions and under the supervision of a physician.
Data on the safety of the drug Solkoseril lactation missing, if necessary, prescribing should stop breastfeeding.
Cautions
In case of adverse reactions should stop using the product and Symptomatic treatment.
Overdose
So far, cases of drug overdose Solkoseril when used according to indications in the recommended doses have not been reported.
Drug Interactions
To apply caution in conjunction with drugs, increases the concentration of potassium in the blood (potassium supplements, potassium-sparing diuretics, ACE inhibitors).
Pharmaceutical interaction
The drug should not be confused when administered with other drugs (especially phytoextracts).
Препарат несовместим с парентеральными формами Ginkgo biloba, naftidrofuryl and bentsiklana fumarate.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
The drug should be stored out of reach of children, dark place at a temperature no higher than 25 ° C. Shelf life – 5 years.
