Sophora tolstoplodnaya – Sophora pachycarpa

Perennial herb 50-60 cm high, leguminous (Fabaceae). It grows mainly in Central Asia. For medical purposes, harvest the aboveground part of plants - grass, from which get the treatment medication hydroiodide pahikarpin. In the native form of the plant in the medical practice is not used.

The chemical composition of Sophora tolstoplodnoy

The most well studied and alkaloid composition of the aboveground parts of the plant. The grass Sophora tolstoplodnoy found biologically active alkaloids pahikarpin, matrin, sofokarpin and other substances.

The pharmacological properties of Sophora tolstoplodnoy

The main alkaloid grass - pahikarpin - blocking N-holinoreaktivnye, However, the degree ganglioblokiruyuschimi activity is considerably inferior to the action gemitona, dikolina, geksonija. Pahikarpin reduces the excitability of the autonomic ganglia of the nervous system and hinders nerve impulses through them. Besides, pahikarpin improves skin tone and enhances the smooth muscle of the uterus, It improves the functional activity of the muscular system in myopathy.

Action pahikarpin CNS poorly expressed and manifested in the increase of inhibitory processes in the higher parts, that has not yet found any practical use in medicine. The pharmacological action of the alkaloid short-lived, It is rapidly absorbed from the gastrointestinal tract, and the drug is widely used in tablet form for oral administration.

The use of drugs in medicine Sophora tolstoplodnoy

Pahikarpin as ganglioplegic used in hypertension crises for relief, when occlusive disease, t. it is. for diseases, involving peripheral vascular spasm. In obstetric practice, the drug is used to speed up the weakness of labor labor contractions or early discharge of amniotic fluid, as well as under weak vain attempts. Due pahikarpin tonic to the uterus the drug is prescribed to reduce blood loss in the postpartum period.

Contraindications. Pahikarpin hydroiodide is contraindicated in pregnancy, when expressed violations of the liver, kidney, Cardiovascular.

Formulations, Dosage and administration of drugs Sophora tolstoplodnoy

Paxikarpina gidrojodid appointed interior, subcutaneously and intramuscularly. When occlusive disease are inside of 0.05-0.1 g 2-3 times a day. Treatment carried out for 3-6 weeks. When ganglionitis designate the interior of 0.05-0.1 g 2 twice a day for 10-15 days. If myopathy appointed interior 0,1 g 2 twice a day for 40-50 days. The course of treatment can be repeated 2-3 times in 1-3 months.

To stimulate labor appoint intramuscularly or subcutaneously at 2-4 ml 3 % solution (less inside of 0.1-0.15 g per reception); 1-2 h drug can be re-entered. The stimulating effect begins to emerge after 5-30 min after administration pahikarpin. For greater efficiency can be administered at the same time inside of quinine 0,2 g every 30 m. When subinvolution uterus postpartum give pahikarpin inward 0,1 g 2-3 times a day.

For use in obstetric practice pahikarpin issued in the form of rectal suppositories 0,1 g.

Higher doses for adults inside: single 0,2 g, daily 0,6 g; under the skin: single 0,15 g (5 ml 3 % solution), daily 0,45 g (15 ml 3 % solution).