When ATH:

Pharmacological action

Antimicrobial and antiprotozoal agent, synthetic derivative of nitroimidazole.

It is active against obligate anaerobic bacteria (slowly- and nesporoobrazuющih), Some agents of protozoal infections: Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica.

Not active against aerobic bacteria.

It increases the sensitivity of tumors to radiation, causing sensitization to ethanol (disulfiramopodobnyh action). Interaction with DNA, It is a violation of the spiral structure, break threads, inhibition of the synthesis of nucleic acids and cell death.


Seknidazol has a high degree of absorption, bioavailability of 80%. It is metabolized in the liver. Cmax after a single oral administration 2 Mr. achieved through 4 no. Report the news: during 72 no – 16% of the dose. Provided with breast milk, It crosses the placental barrier.


Trihomonadnыe uretritы and vaginitы, intestinal amebiasis, hepatic amoebiasis, giardiasis.

Dosage regimen

For oral dose for adults is 2 g / day, for children – 30 mg / kg / day in one or more steps. A course of treatment – from 1 to 5 days.

Side effect

Often: dyspeptic symptoms (incl. nausea, pain in the stomach), metallic taste in mouth, glossitis, stomatitis, moderate reversible leukopenia, hives.

Rarely: dizziness, incoordination, ataxia, paresthesia, polyneuropathy.


Organic diseases of the central nervous system, pathological changes in peripheral blood (incl. history), pregnancy, lactation (breast-feeding), Hypersensitivity to imidazole derivatives.

Pregnancy and lactation

Seknidazol is contraindicated during pregnancy and lactation (breast-feeding).

It penetrates through the placental barrier. Clinical data on the safety of use in pregnancy. In experimental studies have not revealed teratogenic effects seknidazol.

Seknidazol excreted in breast milk, therefore, if necessary, use during lactation should stop breastfeeding.


During treatment to avoid the use of alcohol.

Drug Interactions

In an application with anticoagulants seknidazol (coumarin derivatives or indandiona) action of the latter can be enhanced, so you should periodically monitor the prothrombin time and adjust the dose of anticoagulants.

In an application seknidazol with disulfiram may develop paranoid reactions and psychosis; ethanol – may develop effects, similar to the action of disulfiram (stomach cramps, nausea, vomiting, headache, a sudden rush of blood to the face).

Do not combine with non-depolarizing muscle relaxants (vekuroniya bromide).

At simultaneous reception with lithium seknidazol increases its concentration in plasma.

In combination with amoxicillin increased activity against Helicobacter pylori (amoxicillin suppresses development of resistance).

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