Kaposi's Sarcoma – Tumor blood vessels

Kaposi's Sarcoma

Kaposi's sarcoma - idiopathic hemorrhagic sarcoma. Ill mostly elderly men and young people, suffering from AIDS. In children it is rare. It can be observed with different members of the same family.

There are early and late stages of tumor growth. At an early stage in the hands and feet appear multiple, sometimes symmetrical, itchy, components and painful reddish plaques, increasing very slowly (years may be unchanged). In the process of development, they merge, ulcerate. Skin, coating units, cyanotic, edematous, appear hemorrhage, observed the spontaneous formation of scars and pigmented areas or generalization to form lung metastases, lymph nodes, digestive organs. Characterized by relapses.

The pathogenesis of Kaposi's sarcoma has not been elucidated. There are three viewpoints, according to which the Kaposi's sarcoma is considered as a kind of angiomatosis, as a sarcoma or inflammatory granulomatous process. In the early stage of the disease is mainly found in cytologically cells productive inflammation (gistiocitы, lymphoid cells, plasmacytes, macrophages) with lots of hemosiderin.

In the later stage of Kaposi's sarcoma among the elements productive inflammation are vznachitelnom number of atypical spindle cells and irregularly shaped nuclei with large polymorphic, containing hypertrophied nucleoli. Their cytoplasm basophilic, Homogeneous, sometimes fibrillar structure. Cells arranged beams, tyazhami, often some scraps of capillaries, are found in the tissue scraps. There mitotic figures. Characterized by the presence of grain hemosiderin, disposed within macrophages, and the decay of the past - extracellularly. Sometimes very small hemosiderin, elements productive inflammation (gistiocitы, lymphocytes, plasma cells, endothelial, macrophages with gemosiderinom) - In a small amount.

The cytologic conclusion should indicate, that described atypical cells may occur as in Kaposi's sarcoma, and when fibrosarcoma.