Salicylamide

When ATH:
N02BA05

Characteristic.

White or slightly pink crystalline powder, slightly bitter taste. Sublime when heated. Solubility in water at 30 °C — 0,2%; at 47 °C — 0,8%, glycerine in 5 °C — 2,0%, at 39 °C — 5,0%, at 60 °C — 10,0%, in propilenglikole when 5 °C — 10,0%. Soluble in hot water, ethanol, xloroforme, ether. the pH of the aqueous solutions saturated with 28 ° C approx. 5. Molecular weight - 137,14. At pH 9 forms a water-soluble sodium salt.

Pharmacological action.

Application.

Feverish syndrome (colds and infectious diseases); pain of mild to moderate intensity: arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea; pain in trauma, burns; inflammatory diseases of the joints (rheumatoid arthritis, reactive arthritis, osteoarthritis, spondyloarthropathy, ankylosing spondylitis, gout) and soft tissue (ʙursit, tendinitis); revmokardit.

Contraindications.

Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract, gastric ulcer and duodenal ulcer, yazvennыy colitis; bronchial asthma, heart failure, swelling, arterial hypertension, hemophilia, hypocoagulation state, kidney and / or liver failure, hearing loss, pathology of the vestibular apparatus, deficiency of glucose-6-fosfatdegidrogenazы, blood disease.

Restrictions apply.

Pregnancy, lactation.

Side effects.

From the nervous system and sensory organs: headache, dizziness, hearing loss, noise in ears.

Cardio-vascular system and blood (hematopoiesis, hemostasis): heart failure, increased blood pressure, agranulocytosis, leukopenia, thrombocytopenia, anemia.

From the digestive tract: NSAID-gastropathy: abdominal pain, nausea, vomiting, heartburn, diarrhea.

Other: bleeding: gastrointestinal, gingival, Uterine, hemorrhoidal; bronchospasm, swelling, the liver and kidneys, increased sweating; allergic reactions; with long-term use in high doses is pitting gastrointestinal mucosa, bleeding.

Cooperation.

Inductors of microsomal oxidation (incl. phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites; Ethanol contributes to the development of acute pancreatitis. It enhances the activity of anticoagulants, antiagregantov, fibrinolitikov, as well as side effects mineralogy- and glucocorticoids, estrogen, scarp- and nephrotoxic agents. Reduces the effectiveness of drugs urikozuricheskih, hypotensive diuretics and. Antacids reduce the absorption and cholestyramine.

Dosing and Administration.

Inside, after meal, drinking plenty of water; as an analgesic and antipyretic, adults on 0.5-0.25 g 2-3 times a day, rheumatism 0.5-1 g 3-8 times a day. The maximum daily dose 8 g / day. Children with acute attacks of rheumatism at the rate of 0.4-0.5 g 1 year of life.

Precautions.

During treatment it is necessary to control the picture of peripheral blood and functional state of the liver.